Large non-coding RNAs: missing links in cancer?

被引：434

作者：

Huarte, Maite ^{[1
,2
]}

Rinn, John L. ^{[1
,2
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pathol, Boston, MA 02215 USA

来源：

HUMAN MOLECULAR GENETICS | 2010年 / 19卷

关键词：

PROSTATE-SPECIFIC GENE; PROTEIN-CODING RNA; SNORNA HOST GENE; GROWTH-ARREST; ACTIVATOR SRA; BINDING-PROTEINS; PSF PROTEIN; CELL-GROWTH; H19; GENE; VL30; RNA;

D O I：

10.1093/hmg/ddq353

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular homeostasis is achieved by the proper balance of regulatory networks that if disrupted can lead to cellular transformation. These cell circuits are fine-tuned and maintained by the coordinated function of proteins and non-coding RNAs (ncRNAs). In addition to the well-characterized protein coding and microRNAs constituents, large ncRNAs are also emerging as important regulatory molecules in tumor-suppressor and oncogenic pathways. Recent studies have revealed mechanistic insight of large ncRNAs regulating key cancer pathways at a transcriptional, post-transcriptional and epigenetic level. Here we synthesize these latest advances within the context of their mechanistic roles in regulating and maintaining cellular equilibrium. We posit that similar to protein-coding genes, large ncRNAs are a newly emerging class of oncogenic and tumor-suppressor genes. Our growing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potential use as biomarkers and targets for novel therapeutic approaches in the future.

引用

页码：R152 / R161

页数：10

共 99 条

[11] Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes [J].

Calin, George A. ;

Croce, Carlo M. .

BLOOD, 2009, 114 (23) :4761-4770

[12] The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA - Eclectic regulators of disparate biological functions [J].

Caretti, Giuseppina ;

Lei, Elissa P. ;

Sartorelli, Vittorio .

CELL CYCLE, 2007, 6 (10) :1172-1176

[13] The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation [J].

Caretti, Giuseppina ;

Schiltz, R. Louis ;

Dilworth, F. Jeffrey ;

Di Padova, Monica ;

Zhao, Po ;

Ogryzko, Vasily ;

Fuller-Pace, Frances V. ;

Hoffman, Eric P. ;

Tapscott, Stephen J. ;

Sartorelli, Vittorio .

DEVELOPMENTAL CELL, 2006, 11 (04) :547-560

[14] The transcriptional landscape of the mammalian genome [J].

Carninci, P ;

Kasukawa, T ;

Katayama, S ;

Gough, J ;

Frith, MC ;

Maeda, N ;

Oyama, R ;

Ravasi, T ;

Lenhard, B ;

Wells, C ;

Kodzius, R ;

Shimokawa, K ;

Bajic, VB ;

Brenner, SE ;

Batalov, S ;

Forrest, ARR ;

Zavolan, M ;

Davis, MJ ;

Wilming, LG ;

Aidinis, V ;

Allen, JE ;

Ambesi-Impiombato, X ;

Apweiler, R ;

Aturaliya, RN ;

Bailey, TL ;

Bansal, M ;

Baxter, L ;

Beisel, KW ;

Bersano, T ;

Bono, H ;

Chalk, AM ;

Chiu, KP ;

Choudhary, V ;

Christoffels, A ;

Clutterbuck, DR ;

Crowe, ML ;

Dalla, E ;

Dalrymple, BP ;

de Bono, B ;

Della Gatta, G ;

di Bernardo, D ;

Down, T ;

Engstrom, P ;

Fagiolini, M ;

Faulkner, G ;

Fletcher, CF ;

Fukushima, T ;

Furuno, M ;

Futaki, S ;

Gariboldi, M .

SCIENCE, 2005, 309 (5740) :1559-1563

[15] Non-coding RnA transcription: turning on neighbours [J].

Carninci, Piero .

NATURE CELL BIOLOGY, 2008, 10 (09) :1023-1024

[16] Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer [J].

Cheung, H. H. ;

Lee, T. L. ;

Davis, A. J. ;

Taft, D. H. ;

Rennert, O. M. ;

Chan, W. Y. .

BRITISH JOURNAL OF CANCER, 2010, 102 (02) :419-427

[17]

CHO WCS, 2007, MOL CANCER, V6

[18] REGULATION AND EXPRESSION OF A GROWTH ARREST-SPECIFIC GENE (GAS5) DURING GROWTH, DIFFERENTIATION, AND DEVELOPMENT [J].

COCCIA, EM ;

CICALA, C ;

CHARLESWORTH, A ;

CICCARELLI, C ;

ROSSI, GB ;

PHILIPSON, L ;

SORRENTINO, V .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (08) :3514-3521

[19] The RNA coregulator SRA, its binding proteins and nuclear receptor signaling activity [J].

Colley, Shane M. ;

Iyer, Kavitha R. ;

Leedman, Peter J. .

IUBMB LIFE, 2008, 60 (03) :159-164

[20]

Colley SM, 2009, CRIT REV BIOCHEM MOL, V44, P25, DOI [10.1080/10409230802661719, 10.1080/10409230802661719 ]

← 1 2 3 4 5 6 7 8 9 10 →