Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy

被引:97
作者
Liu, Yanlan [1 ,2 ]
Ji, Xiaoyuan [1 ,2 ,3 ,4 ]
Liu, Jianhua [5 ]
Tong, Winnie W. L. [1 ,2 ]
Askhatova, Diana [1 ,2 ]
Shi, Jinjun [1 ,2 ]
机构
[1] Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
[3] Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[5] Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Jilin, Peoples R China
关键词
cancer therapy; CT imaging; drug delivery; hyperthermia; TaS2; nanosheets; TRIGGERED DRUG-DELIVERY; CANCER-THERAPY; IN-VIVO; SOLID TUMORS; NANOPARTICLES; FACILE; AGENT; NANOMEDICINES; NANOMATERIALS; HYPERTHERMIA;
D O I
10.1002/adfm.201703261
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications. However, Ta-based nanomaterials by themselves have not been explored for NIR-mediated photothermal ablation therapy. In this work, an innovative Ta-based multifunctional nanoplatform composed of biocompatible tantalum sulfide (TaS2) nanosheets (NSs) is reported for simultaneous NIR hyperthermia, drug delivery, and computed tomography (CT) imaging. The TaS2 NSs exhibit multiple unique features including (i) efficient NIR light-to-heat conversion with a high photothermal conversion efficiency of 39%, (ii) high drug loading (177% by weight), (iii) controlled drug release triggered by NIR light and moderate acidic pH, (iv) high tumor accumulation via heat-enhanced tumor vascular permeability, (v) complete tumor ablation and negligible side effects, and (vi) comparable CT imaging contrast efficiency to the widely clinically used agent iobitridol. It is expected that this multifunctional NS platform can serve as a promising candidate for imaging-guided cancer therapy and selection of cancer patients with high tumor accumulation.
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页数:12
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