Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle

被引：88
|
作者：
Li, Y [1 ]
Shan, F
Wu, JM
Wu, GS
Ding, J
Xiao, D
Yang, WY
Atassi, G
Léonce, S
Caignard, DH
Renard, P
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Synthet Chem, Shanghai 200031, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Pharmacol, Shanghai 200031, Peoples R China
[3] Inst Rech Servier, F-92150 Suresnes, France
[4] ADIR & Co, Courbevoie, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(00)00578-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P388 and A549 cells. This activity was reflected in P388 murine leukemia by an accumulation of cells in G1 phase, and induction of apoptosis. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：5 / 8
页数：4
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