Biomarkers for Diagnosis and Prognosis of AKI in Children One Size Does Not Fit All

被引：64
作者：
Greenberg, Jason H. [1 ,2 ]
Parikh, Chirag R. [2 ,3 ,4 ]
机构：
[1] Yale Univ, Sch Med, Dept Pediat, Nephrol Sect, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Program Appl Translat Res, New Haven, CT USA
[3] Yale Univ, Sch Med, Dept Internal Med, Nephrol Sect, New Haven, CT 06510 USA
[4] Vet Affairs Med Ctr, West Haven, CT USA
来源：
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2017年 / 12卷 / 09期
基金：
美国国家卫生研究院;
关键词：
ACUTE KIDNEY INJURY; GELATINASE-ASSOCIATED LIPOCALIN; ACID-BINDING PROTEIN; SERUM CYSTATIN C; CARDIAC BIOMARKERS; URINE BIOMARKERS; REFERENCE VALUES; GESTATIONAL-AGE; PERFORMANCE; CREATININE;
D O I：
10.2215/CJN.12851216
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Pediatric AKI has become a significant health concern due to its rising incidence and association with adverse outcomes. Because of the limitations of serum creatinine, ongoing research has evaluated multiple novel biomarkers for the early detection of AKI. Identifying biomarkers that precede changes in serum creatinine is vital, because these biomarkers provide opportunities to improve outcomes through early diagnosis and timely disease management. In this review, we discuss salient findings on 16 candidate biomarkers and their association with AKI. We explore the differences in biomarker distribution by age and discuss why adult biomarker research findings cannot be directly extrapolated to children. With future research, more consideration needs to be given to how the maturing kidney affects biomarker levels and how we interpret biomarker performance in children. A comprehensive approach using age-specific biomarker reference ranges is required to develop pediatric biomarkers and improve outcomes for children with kidney disease.
引用
收藏
页码：1551 / 1557
页数：7
相关论文
共 46 条
[31]  
Mishra Jaya, 2005, Lancet, V365, P1231, DOI 10.1016/S0140-6736(05)74811-X
[32]   Preoperative serum h-FABP concentration is associated with postoperative incidence of acute kidney injury in patients undergoing cardiac surgery [J].
Oezkur, Mehmet ;
Gorski, Armin ;
Peltz, Jennifer ;
Wagner, Martin ;
Lazariotou, Maria ;
Schimmer, Christoph ;
Heuschmann, Peter U. ;
Leyh, Rainer G. .
BMC CARDIOVASCULAR DISORDERS, 2014, 14 :1-6
[33]   Variation in Performance of Kidney Injury Biomarkers Due to Cause of Acute Kidney Injury [J].
Parikh, Chirag R. ;
Han, Gang .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2013, 62 (06) :1023-1026
[34]   Performance of Kidney Injury Molecule-1 and Liver Fatty Acid-Binding Protein and Combined Biomarkers of AKI after Cardiac Surgery [J].
Parikh, Chirag R. ;
Thiessen-Philbrook, Heather ;
Garg, Amit X. ;
Kadiyala, Deepak ;
Shlipak, Michael G. ;
Koyner, Jay L. ;
Edelstein, Charles L. ;
Devarajan, Prasad ;
Patel, Uptal D. ;
Zappitelli, Michael ;
Krawczeski, Catherine D. ;
Passik, Cary S. ;
Coca, Steven G. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 8 (07) :1079-1088
[35]   Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery [J].
Parikh, Chirag R. ;
Coca, Steven G. ;
Thiessen-Philbrook, Heather ;
Shlipak, Michael G. ;
Koyner, Jay L. ;
Wang, Zhu ;
Edelstein, Charles L. ;
Devarajan, Prasad ;
Patel, Uptal D. ;
Zappitelli, Michael ;
Krawczeski, Catherine D. ;
Passik, Cary S. ;
Swaminathan, Madhav ;
Garg, Amit X. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (09) :1748-1757
[36]   Impact of gestational age, sex, and postnatal age on urine biomarkers in premature neonates [J].
Saeidi, Behtash ;
Koralkar, Rajesh ;
Griffin, Russell L. ;
Halloran, Brian ;
Ambalavanan, Namasivayam ;
Askenazi, David J. .
PEDIATRIC NEPHROLOGY, 2015, 30 (11) :2037-2044
[37]   Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery [J].
Schaub, Jennifer A. ;
Garg, Amit X. ;
Coca, Steven G. ;
Testanil, Jeffrey M. ;
Shlipak, Michael G. ;
Eikelboom, John ;
Kavsak, Peter ;
McArthur, Eric ;
Shortt, Colleen ;
Whitlock, Richard ;
Parikh, Chirag R. .
KIDNEY INTERNATIONAL, 2015, 88 (03) :576-583
[38]   Acute Kidney Injury in Asphyxiated Newborns Treated with Therapeutic Hypothermia [J].
Selewski, David T. ;
Jordan, Brian K. ;
Askenazi, David J. ;
Dechert, Ronald E. ;
Sarkar, Subrata .
JOURNAL OF PEDIATRICS, 2013, 162 (04) :725-+
[39]  
SHORE GM, 1975, AM J CLIN PATHOL, V63, P245
[40]   Pediatric pharmacology in the first year of life [J].
Sumpter, Anita ;
Anderson, Brian J. .
CURRENT OPINION IN ANESTHESIOLOGY, 2009, 22 (04) :469-475
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