HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma

被引：26

作者：

Jiang, Honghong ^{[1
,2
,3
]}

Fu, Qiaofen ^{[1
,2
]}

Song, Xin ^{[1
,2
]}

Ge, Chunlei ^{[2
]}

Li, Ruilei ^{[2
]}

Li, Zhen ^{[2
]}

Zeng, Baozhen ^{[2
]}

Li, Chunyan ^{[2
]}

Wang, Ying ^{[2
]}

Xue, Yuanbo ^{[2
]}

Luo, Rongcheng ^{[1
]}

Fang, Weiyi ^{[1
]}

机构：

[1] Southern Med Univ, Integrated Hosp Tradit Chinese Med, Canc Ctr, 13 ShiLiuGang Rd, Guangzhou 510315, Guangdong, Peoples R China

[2] Kunming Med Univ, Affiliated Hosp 3, Tumour Hosp Yunnan Prov, Dept Canc Biotherapy Ctr, Kunming 510118, Yunnan, Peoples R China

[3] Jinan Univ, Guangzhou Red Cross Hosp, Dept Ultrasound, Med Coll, Guangzhou 510220, Guangdong, Peoples R China

来源：

ONCOLOGY LETTERS | 2019年 / 18卷 / 05期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

hepatoma-derived growth factor; protein kinase C alpha; lung adenocarcinoma; GROWTH-FACTOR; EXPRESSION; CANCER; NSCLC; EGFR; TRANSCRIPTION; PROGRESSION; CARCINOMA; BIOPSIES; SMOKING;

D O I：

10.3892/ol.2019.10812

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung adenocarcinoma is the most common histologic subtype of lung cancer. The aim of the present study was to assess the expression of hepatoma-derived growth factor (HDGF) and protein kinase C alpha (PRKCA) in lung adenocarcinoma (LADC), and to determine the association between the combined expression of these two proteins and clinicopathological characteristics of patients with LADC. The expression of HDGF and PRKCA mRNA was assessed by GEO database analysis, and HDGF and PRKCA protein levels were examined by immunohistochemistry using a tissue microarray. High HDGF and PRKCA expression was observed in LADC tissue compared to normal samples, and increased HDGF and PRKCA expression was associated with AJCC clinical stage, tumor classification, node classification, and lymph node metastasis. GEO database analysis revealed no significant differences between HDGF mRNA and PRKCA mRNA in LADC tissue. However, high PRKCA protein expression was associated with high HDGF protein expression, and patients with high HDGF and PRKCA expression exhibited poorer overall survival rates than patients with low expression levels of the two proteins. The results of the present study suggest that upregulation of both HDGF and PRKCA may be an unfavourable factor for lung adenocarcinoma progression.

引用

页码：4936 / 4946

页数：11

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