Calcineurin Regulates Coelomocyte Endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans

被引：7

作者：

Song, Hyun-Ok ^{[1
]}

Lee, Jungsoo ^{[1
]}

Ji, Yon Ju ^{[1
]}

Dwivedi, Meenakshi ^{[1
]}

Cho, Jeong Hoon ^{[2
]}

Park, Byung-Jae ^{[3
]}

Ahnn, Joohong ^{[1
]}

机构：

[1] Hanyang Univ, Coll Nat Sci, Dept Life Sci, Seoul 133791, South Korea

[2] Chosun Univ, Coll Educ, Div Biol Educ, Kwangju 501759, South Korea

[3] Hallym Univ, Dept Life Sci, Chunchon 200702, South Korea

来源：

MOLECULES AND CELLS | 2010年 / 30卷 / 03期

关键词：

Ca2+ signaling; C; elegans; endocytosis; phosphatase; DEPENDENT PROTEIN PHOSPHATASE; SYNAPTIC VESICLE ENDOCYTOSIS; TRANSCRIPTION FACTOR NFAT1; DYNAMIN-I; MEDIATED ENDOCYTOSIS; DEPHOSPHORYLATION; HOMOLOG; SHIBIRE; BINDS; CDK5;

D O I：

10.1007/s10059-010-0116-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C. elegans coelomocytes are macrophage-like scavenger cells that provide an excellent in vivo system for the study of clathrin-mediated endocytosis. Using this in vivo system, several genes involved in coelomocyte endocytosis have been identified previously. However, the detailed mechanism of endocytic pathway is still unknown. Here, we report a new function of calcineurin, an evolutionarily conserved Ca2+/calmodulin-dependent Ser/Thr protein phosphatase, in coelomocyte endocytosis. We found that calcineurin mutants show defective coelomocyte endocytosis. Genetic analysis suggests that calcineurin and a GTPase, dynamin (DYN-1), may function upstream of an orphan receptor, CUP-4, to regulate endocytosis. Therefore, we propose a model in which calcineurin may regulate coelomocyte endocytosis via DYN-1 and CUP-4 in C. elegans.

引用

页码：255 / 262

页数：8