Deceased donors with a past history of malignancy: An Organ Procurement and Transplantation Network/United Network for Organ Sharing update

被引:102
作者
Kauffman, H. Myron
Cherikh, Wida S.
McBride, Maureen A.
Cheng, Yulin
Hanto, Douglas W.
机构
[1] United Network Organ Sharing, Res Dept, Richmond, VA 23219 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
关键词
organ donation; cancer history; tumor transmission;
D O I
10.1097/01.tp.0000267919.93425.fb
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Approximately 2% of deceased donor organ transplants result from donors with a past history of cancer. An analysis of Organ Procurement and Transplantation Network/United Network for Organ Sharing data on 39,455 deceased donors from 2000 to 2005 showed 1069 donors had a PHC, resulting in 2508 transplants, including 1236 kidneys, 891 livers, 199 hearts, 100 lungs, and 82 miscellaneous organs. The most common type of previous cancer in the donor was nonmelanoma skin cancer (n=776) followed by central nervous system malignancies (n=642) and carcinoma of the uterine cervix (n=336). One donor with a glioblastoma multiforme transmitted fatal tumors to three recipients. One donor with a history of melanoma 32 years earlier transmitted a fatal melanoma to a single recipient and, therefore, donors with a history of melanoma should not be used. Donors with a past history of cancer who have a nontraumatic cerebral hemorrhage cause concern because this hemorrhage may be the result of an unrecognized metastatic tumor.
引用
收藏
页码:272 / 274
页数:3
相关论文
共 7 条
[1]   Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: Case study and review of the literature [J].
Armanios, MY ;
Grossman, SA ;
Yang, SC ;
White, B ;
Perry, A ;
Burger, PC ;
Orens, JB .
NEURO-ONCOLOGY, 2004, 6 (03) :259-263
[2]   Transplant tumor registry: Donor related malignancies [J].
Kauffman, HM ;
McBride, MA ;
Cherikh, WS ;
Spain, PC ;
Marks, WH ;
Roza, AM .
TRANSPLANTATION, 2002, 74 (03) :358-362
[3]   First report of the united network for organ sharing transplant tumor registry: Donors with a history of cancer [J].
Kauffman, HM ;
McBride, MA ;
Delmonic, FL .
TRANSPLANTATION, 2000, 70 (12) :1747-1751
[4]  
KAUFFMAN HM, 2002, TRANSPLANT REV, V16, P177
[5]  
Penn I, 1994, Transplant Sci, V4, P23
[6]   Late metastases of cutaneous melanoma:: An analysis of 31 patients [J].
Schmid-Wendtner, MH ;
Baumert, J ;
Schmidt, M ;
Konz, B ;
Hölzel, D ;
Plewig, G ;
Volkenandt, M .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2000, 43 (04) :605-609
[7]  
Tsao HS, 1997, CANCER, V79, P2361