Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α

被引：75

作者：

Aljabali, Alaa A. A. ^{[1
]}

Bakshi, Hamid A. ^{[2
]}

Hakkim, Faruck L. ^{[3
]}

Haggag, Yusuf A. ^{[4
]}

Al-Batanyeh, Khalid M. ^{[5
]}

Al Zoubi, Mazhar S. ^{[6
]}

Al-Trad, Bahaa ^{[5
]}

Nasef, Mohamed M. ^{[7
]}

Satija, Saurabh ^{[8
]}

Mehta, Meenu ^{[8
]}

Pabreja, Kavita ^{[8
]}

Mishra, Vijay ^{[8
]}

Khan, Mohammed ^{[2
]}

Abobaker, Salem ^{[9
]}

Azzouz, Ibrahim M. ^{[10
,11
]}

Dureja, Harish ^{[12
]}

Pabari, Ritesh M. ^{[13
]}

Dardouri, Ashref Ali K. ^{[14
]}

Kesharwani, Prashant ^{[15
]}

Gupta, Gaurav ^{[16
]}

Shukla, Shakti Dhar ^{[17
,18
]}

Prasher, Parteek ^{[19
]}

Charbe, Nitin B. ^{[20
]}

Negi, Poonam ^{[21
]}

Kapoor, Deepak N. ^{[21
]}

Chellappan, Dinesh Kumar ^{[22
]}

da Silva, Mateus Webba ^{[2
]}

Thompson, Paul ^{[23
]}

Dua, Kamal ^{[17
,18
,21
,24
,25
]}

McCarron, Paul ^{[2
]}

Tambuwala, Murtaza M. ^{[2
]}

机构：

[1] Yarmouk Univ, Fac Pharm, Dept Pharmaceut Sci, Irbid 566, Jordan

[2] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[3] Dhofar Univ Salalah, Coll Arts & Appl Sci, Dept Math & Sci, Salalah 211, Oman

[4] Univ Tanta, Fac Pharm, Dept Pharmaceut Technol, Tanta 31111, Egypt

[5] Yarmouk Univ, Fac Sci, Dept Biol Sci, Irbid 566, Jordan

[6] Yarmouk Univ, Fac Sci, Dept Basic Med Sci, Irbid 566, Jordan

[7] Univ Huddersfield, Sch Appl Sci, Dept Pharm & Biomed Sci, Huddersfield HD1 3DH, W Yorkshire, England

[8] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[9] Klinikum Charite Univ Med Berlin, European Competence Ctr Ovarian Canc, Dept Gynecol, Campus Virchow,Augustenburger Pl 1, D-13353 Berlin, Germany

[10] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Charitepl 1, D-10117 Berlin, Germany

[11] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany

[12] Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India

[13] Royal Coll Surgeons Ireland, Sch Pharm, Dublin D02 YN77, Ireland

[14] Huddersfield Univ, Sch Appl Sci, Dept Forens Sci, Huddersfield HD1 3DH, W Yorkshire, England

[15] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

[16] Suresh Gyan Vihar Univ, Sch Pharm, Jaipur 302017, Rajasthan, India

[17] Univ Newcastle, Prior Res Ctr Hlth Lungs, HMRI, Callaghan, NSW 230, Australia

[18] Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW 230, Australia

[19] Univ Petr & Energy Studies, Dept Chem, Dehra Dun 248007, Uttarakhand, India

[20] Pontificia Univ Catolica Chile, Fac Quim & Farm, Dept Quim Organ, Av Vicuna McKenna 4860,7820436 Macul, Santiago 4860, Chile

[21] Shoolini Univ Biotechnol & Management Sci, Sch Pharmaceut Sci, Solan 173229, India

[22] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia

[23] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[24] Univ Technol, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia

[25] Centenary Inst, Ctr Inflammat, Sydney, NSW 2050, Australia

来源：

CANCERS | 2020年 / 12卷 / 01期

关键词：

piceatannol; colon cancer; albumin nanoparticles; nuclear P65; HIF-1; alpha; BOVINE SERUM-ALBUMIN; IN-VITRO; DRUG-DELIVERY; BIODEGRADABLE NANOPARTICLES; CELL-CYCLE; COLITIS; INVASION; CARCINOGENESIS; PROLIFERATION; INFLAMMATION;

D O I：

10.3390/cancers12010113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These PIC-BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1 alpha. Our results indicate that PIC-BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1 alpha in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC-BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC-BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC-BSA NPs, enhances its therapeutic potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possible human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients.

引用

页数：22

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