Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS)

被引：28

作者：

Stone, William S. ^{[1
,2
]}

Giuliano, Anthony J. ^{[1
]}

Tsuang, Ming T. ^{[2
,3
]}

Braff, David L. ^{[3
]}

Cadenhead, Kristin S. ^{[3
]}

Calkins, Monica E. ^{[6
]}

Dobie, Dorcas J. ^{[7
,8
]}

Faraone, Stephen V. ^{[4
,5
]}

Freedman, Robert ^{[10
]}

Green, Michael F. ^{[9
]}

Greenwood, Tiffany A. ^{[3
]}

Gur, Raquel E. ^{[6
]}

Gur, Ruben C. ^{[6
]}

Light, Gregory A. ^{[3
]}

Mintz, Jim ^{[9
]}

Nuechterlein, Keith H. ^{[9
]}

Olincy, Ann ^{[10
]}

Radant, Allen D. ^{[7
,8
]}

Roe, Andrea H. ^{[1
]}

Schork, Nicholas J. ^{[3
]}

Siever, Larry J. ^{[11
,12
]}

Silverman, Jeremy M. ^{[11
]}

Swerdlow, Neal R. ^{[3
]}

Thomas, Alison R. ^{[1
]}

Tsuang, Debby W. ^{[7
,8
]}

Turetsky, Bruce I. ^{[6
]}

Seidman, Larry J. ^{[1
,2
]}

机构：

[1] Harvard Univ, Massachusetts Mental Hlth Ctr, Beth Israel Deaconess Med Ctr, Publ Psychiat Div,Med Sch, Boston, MA 02215 USA

[2] Harvard Inst Psychiat Epidemiol & Genet, Boston, MA USA

[3] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[4] SUNY Upstate Med Univ, Med Genet Res Program, Syracuse, NY 13210 USA

[5] SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY 13210 USA

[6] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[7] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[8] Dept Vet Affairs VISN 20 Mental Illness Res Educ, Seattle, WA USA

[9] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA

[10] Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA

[11] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

[12] James J Peters VA & VISN3 Mental Illness Res Educ, Bronx, NY USA

来源：

SCHIZOPHRENIA RESEARCH | 2011年 / 128卷 / 1-3期

关键词：

Verbal declarative memory; Schizophrenia; Endophenotype; ANTISACCADE PERFORMANCE; NONPSYCHOTIC RELATIVES; 1ST-EPISODE SCHIZOPHRENIA; BIOLOGICAL RELATIVES; COGNITIVE DEFICITS; MEMORY IMPAIRMENTS; DECLARATIVE MEMORY; WORKING-MEMORY; ENDOPHENOTYPE; HERITABILITY;

D O I：

10.1016/j.schres.2011.01.005

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Genetic studies of schizophrenia focus increasingly on putative endophenotypes because their genetic etiology may be simpler than clinical diagnosis. The Consortium on the Genetics of Schizophrenia (COGS), a multisite family study, aims to identify the genetic basis of several endophenotypes including verbal declarative memory (VDM), a neurocognitive function that shows robust impairment in schizophrenia. We present data on one type of measure of VDM, the California Verbal Learning Test, Second Edition (CVLT-II), in schizophrenia probands (n = 305), their full biological siblings (n = 449) and parents (n = 232), and in community comparison subjects (CCS: n = 509) across seven sites. Probands performed more poorly on each of five CVLT-II measures compared to related sibling and parent groups and CCS. Siblings and parents performed significantly worse than CCS on one measure (Discriminability), but with smaller effect sizes and less impairment than observed previously. The results raise questions about the homogeneity of VDM as an endophenotype, about methodological issues related to sampling, and about psychometric issues that impact the utility of the CVLT for detecting VDM deficits in nonpsychotic relatives of persons with schizophrenia. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：102 / 110

页数：9

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