Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats

被引：43

作者：

Altindag, Fikret ^{[1
]}

Ragbetli, Murat Cetin ^{[1
]}

Ozdek, Ugur ^{[2
]}

Koyun, Necat ^{[3
]}

Alhalboosi, Jamal Khalid Ismael ^{[1
]}

Elasan, Sadi ^{[4
]}

机构：

[1] Van Yuzuncu Yil Univ, Fac Med, Dept Histol & Embryol, TR-65080 Van, Turkey

[2] Van Yuzuncu Yil Univ, Van Vocat Higher Sch Healthcare Studies, Van, Turkey

[3] Van Yuzuncu Yil Univ, Fac Med, Dept Anat, Van, Turkey

[4] Van Yuzuncu Yil Univ, Fac Med, Dept Biostat, Van, Turkey

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2021年 / 156卷

关键词：

Diabetes mellitus; Ellagic acid; Immunohistochemistry; Pancreas; Rat; Sinapic acid; Stereology; Streptozotocin; OXIDATIVE STRESS; ANTIOXIDANT; LIVER; COMPLICATIONS; DEGENERATION; PATHOGENESIS; APOPTOSIS; PANCREAS; MELLITUS; EXTRACT;

D O I：

10.1016/j.fct.2021.112443

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In the present study, we aimed to investigate the effect of individual and combined treatment of sinapic acid (SA) and ellagic acid (EA) in streptozotocin (STZ)-induced diabetic rats. Rats were divided into eight groups (n = 7): Normal Control, Diabetic Control, Diabetic + Sinapic Acid, Diabetic + Ellagic Acid, Diabetic + Sinapic Acid + Ellagic Acid, Sinapic Acid, Ellagic Acid and Sinapic Acid + Ellagic Acid. Diabetic groups were injected with a single dose of 50 mg/kg STZ intraperitoneally. Rats received 20 mg/kg/day SA and 50 mg/kg/day EA intragastrically for 28 days. The numerical density of immunopositive beta-cells and volume density of pancreatic islets were calculated. Additionally, glucose and insulin levels in serum, MDA, GSH, and CAT levels of pancreatic tissue were measured. While serum glucose levels increased, serum insulin levels decreased in STZ-induced diabetic rats. But these changes in glucose and insulin were restored by individual and combined treatments of SA and EA. Also, individual and combined treatments of SA and EA increased insulin expression of beta-cells in STZ-induced diabetic rats. Moreover, these compounds improved deteriorating oxidative stress parameters in STZ-induced diabetic rats. Our study indicates that SA and EA, especially their combined treatments, can be used as an antihyperglycemic agent in diabetes.

引用

页数：8

共 53 条

[1]

Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO

[2]

2-S

[3] Protective Effects of Chitosan and Chitosan Oligosaccharide on Sodium Fluoride-Induced Testicular Damage in Male Rats: A Stereological and Histopathological Study [J].

Altindag, Fikret ;

Ozdek, Ugur .

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, 2021, 27 (02) :183-189

[4] The effect of maternal treatment with diclofenac sodium and thymoquinone on testicular parameters in rat offspring [J].

Altindag, Fikret ;

Ragbetli, Murat Cetin .

REVISTA INTERNACIONAL DE ANDROLOGIA, 2021, 19 (01) :34-40

[5] Sinapic acid modulates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats [J].

Ansari, Mushtaq Ahmad .

BIOMEDICINE & PHARMACOTHERAPY, 2017, 93 :646-653

[6] Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study [J].

Arya, Aditya ;

Al-Obaidi, Mazen M. Jamil ;

Shahid, Nayiar ;

Bin Noordin, Mohamed Ibrahim ;

Looi, Chung Yeng ;

Wong, Won Fen ;

Khaing, Si Lay ;

Mustafa, Mohd Rais .

FOOD AND CHEMICAL TOXICOLOGY, 2014, 71 :183-196

[7] TRADITIONAL PLANT MEDICINES AS TREATMENTS FOR DIABETES [J].

BAILEY, CJ ;

DAY, C .

DIABETES CARE, 1989, 12 (08) :553-564

[8] Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia [J].

Basu, Rita ;

Barosa, Cristina ;

Jones, John ;

Dube, Simmi ;

Carter, Rickey ;

Basu, Ananda ;

Rizza, Robert A. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (03) :E409-E417

[9] ROLE OF OXIDATIVE STRESS IN DEVELOPMENT OF COMPLICATIONS IN DIABETES [J].

BAYNES, JW .

DIABETES, 1991, 40 (04) :405-412

[10]

BEUTLER E, 1963, J LAB CLIN MED, V61, P882

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