From rigidity to conformational flexibility:: Macrocyclic templates derived from ansa-steroids

被引：16

作者：

Bäurle, S ^{[1
]}

Blume, T ^{[1
]}

Mengel, A ^{[1
]}

Parchmann, C ^{[1
]}

Skuballa, W ^{[1
]}

Bäsler, S ^{[1
]}

Schäfer, M ^{[1
]}

Sülzle, D ^{[1
]}

Wrona-Metzinger, HP ^{[1
]}

机构：

[1] Schering AG, Res Ctr Europe, D-13342 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 33期

关键词：

conformations; macrocycles; ring expansions; steroids;

D O I：

10.1002/anie.200351385

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

More than a curiosity in the field of steroid derivatives, the 17-membered macrocycle 1 was obtained from a more rigid ansa-steroid. Compound 1 serves as a prototype of a template with differentiable functional groups, which can be used in the synthesis of libraries of novel macrocycles.

引用

页码：3961 / 3964

页数：4

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