From rigidity to conformational flexibility:: Macrocyclic templates derived from ansa-steroids

被引：15

作者：

Bäurle, S ^{[1
]}

Blume, T ^{[1
]}

Mengel, A ^{[1
]}

Parchmann, C ^{[1
]}

Skuballa, W ^{[1
]}

Bäsler, S ^{[1
]}

Schäfer, M ^{[1
]}

Sülzle, D ^{[1
]}

Wrona-Metzinger, HP ^{[1
]}

机构：

[1] Schering AG, Res Ctr Europe, D-13342 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 33期

关键词：

conformations; macrocycles; ring expansions; steroids;

D O I：

10.1002/anie.200351385

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

More than a curiosity in the field of steroid derivatives, the 17-membered macrocycle 1 was obtained from a more rigid ansa-steroid. Compound 1 serves as a prototype of a template with differentiable functional groups, which can be used in the synthesis of libraries of novel macrocycles.

引用

页码：3961 / 3964

页数：4

共 26 条

[1] Breinbauer R, 2002, ANGEW CHEM INT EDIT, V41, P2879
[2] BREINBAUER R, 2002, ANGEW CHEM, V114, P3002
[3] CHOWDHURY PK, 1987, LIEBIGS ANN CHEM, P1095
[4] FISCHERHENNINGS.D, 1992, THESIS U HANNOVER
[5] Grabley S, 2000, E SCHERING RES FDN W, V32, P217
[6] Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: A comprehensive survey
Hall, DG
Manku, S
Wang, F
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (02): : 125 - 150
[7] 18-NORANDROSTA-8,11,13-TRIENES .4. 7-HYDROXY-DERIVATIVES
HEWETT, CL
GIBSON, SG
GILBERT, IM
REDPATH, J
SAVAGE, DS
SLEIGH, T
TAYLOR, R
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1975, (04): : 336 - 340
[8] CRYSTAL HANDLING AT LOW-TEMPERATURES
KOTTKE, T
STALKE, D
[J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1993, 26 : 615 - 619
[9] OPENING OF THE MACROCYCLIC RING IN 5,10-8,9-DISECOSTEROIDS (= STEROKLASTANES)
LORENC, L
BONDARENKOGHEORGHIU, L
PAVLOVIC, V
FUHRER, H
KALVODA, J
MIHAILOVIC, ML
[J]. HELVETICA CHIMICA ACTA, 1992, 75 (01) : 203 - 209
[10] 5,10-8,9-DISECOSTEROIDS (= STEROKLASTANES) - A NEW TYPE OF MODIFIED STEROIDS
LORENC, L
BONDARENKO, L
PAVLOVIC, V
FUHRER, H
RIHS, G
KALVODA, J
MIHAILOVIC, ML
[J]. HELVETICA CHIMICA ACTA, 1989, 72 (03) : 608 - 623

← 1 2 3 →