A Versatile and Practical Microwave-Assisted Synthesis of Sterically Hindered N-Arylpiperazines

被引：14
作者：
Gao, Rong [1 ]
Canney, Daniel J. [1 ]
机构：
[1] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19140 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 21期
关键词：
SELECTIVE ANTAGONISTS; PIPERAZINE NITROGENS; RAPID SYNTHESIS; EFFICIENT; DERIVATIVES; RECEPTOR; POTENT; HETEROCYCLIZATION; ARYLATION; AMINES;
D O I：
10.1021/jo101478c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A wide-ranging and practical synthesis of structurally diverse, sterically hindered N-arylpiperazines from 2,2'-(4-nitro-phenylsulfonylazanediyl) bis(ethane-2, 1-diyl) bis(4-nitro-benzenesulfonate) and substituted anilines has been achieved using microwave irradiation in acetonitrile followed by deprotection with PhSH.
引用
收藏
页码：7451 / 7453
页数：3
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