CellPublisher: a web platform for the intuitive visualization and sharing of metabolic, signalling and regulatory pathways

被引:12
作者
Florez, Lope A. [1 ]
Lammers, Christoph R. [1 ]
Michna, Raphael [1 ]
Stuelke, Joerg [1 ]
机构
[1] Univ Gottingen, Dept Gen Microbiol, D-37077 Gottingen, Germany
关键词
NETWORKS; TOOL; GENE;
D O I
10.1093/bioinformatics/btq585
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Systems biology relies increasingly on collaborations between several groups with different expertise. Therefore, the systems biology community is adopting standards that allow effective communication of concepts, as well as transmission and processing of pathway information. The Systems Biology Graphical Notation (SBGN) is a graphical language for biological pathways that has both a biological as well as a computational meaning. The program CellDesigner allows the codification of biological phenomena in an SBGN compliant form. CellPublisher is a web server that allows the conversion of CellDesigner files to web-based navigatable diagrams based on the user interface of Google maps. Thus, CellPublisher complements CellDesigner by facilitating the understanding of complex diagrams and by providing the possibility to share any CellDesigner diagram online with collaborators and get their feedback. Due to the intuitive interface of the online diagrams, CellPublisher serves as a basis for discovery of novel properties of the modelled networks.
引用
收藏
页码:2997 / 2999
页数:3
相关论文
共 9 条
[1]   Pathway databases and tools for their exploitation: benefits, current limitations and challenges [J].
Bauer-Mehren, Anna ;
Furlong, Laura I. ;
Sanz, Ferran .
MOLECULAR SYSTEMS BIOLOGY, 2009, 5
[2]   CellDesigner 3.5: A versatile modeling tool for biochemical networks [J].
Funahashi, Akira ;
Matsuoka, Yukiko ;
Jouraku, Akiya ;
Morohashi, Mineo ;
Kikuchi, Norihiro ;
Kitano, Hiroaki .
PROCEEDINGS OF THE IEEE, 2008, 96 (08) :1254-1265
[3]   Mining Biological Pathways Using WikiPathways Web Services [J].
Kelder, Thomas ;
Pico, Alexander R. ;
Hanspers, Kristina ;
van Iersel, Martijn P. ;
Evelo, Chris ;
Conklin, Bruce R. .
PLOS ONE, 2009, 4 (07)
[4]   Pathway Projector: Web-Based Zoomable Pathway Browser Using KEGG Atlas and Google Maps API [J].
Kono, Nobuaki ;
Arakawa, Kazuharu ;
Ogawa, Ryu ;
Kido, Nobuhiro ;
Oshita, Kazuki ;
Ikegami, Keita ;
Tamaki, Satoshi ;
Tomita, Masaru .
PLOS ONE, 2009, 4 (11) :A47-A56
[5]   Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis [J].
Lammers, Christoph R. ;
Florez, Lope A. ;
Schmeisky, Arne G. ;
Roppel, Sebastian F. ;
Maeder, Ulrike ;
Hamoen, Leendert ;
Stuelke, Joerg .
MICROBIOLOGY-SGM, 2010, 156 :849-859
[6]   The Systems Biology Graphical Notation [J].
Le Novere, Nicolas ;
Hucka, Michael ;
Mi, Huaiyu ;
Moodie, Stuart ;
Schreiber, Falk ;
Sorokin, Anatoly ;
Demir, Emek ;
Wegner, Katja ;
Aladjem, Mirit I. ;
Wimalaratne, Sarala M. ;
Bergman, Frank T. ;
Gauges, Ralph ;
Ghazal, Peter ;
Kawaji, Hideya ;
Li, Lu ;
Matsuoka, Yukiko ;
Villeger, Alice ;
Boyd, Sarah E. ;
Calzone, Laurence ;
Courtot, Melanie ;
Dogrusoz, Ugur ;
Freeman, Tom C. ;
Funahashi, Akira ;
Ghosh, Samik ;
Jouraku, Akiya ;
Kim, Sohyoung ;
Kolpakov, Fedor ;
Luna, Augustin ;
Sahle, Sven ;
Schmidt, Esther ;
Watterson, Steven ;
Wu, Guanming ;
Goryanin, Igor ;
Kell, Douglas B. ;
Sander, Chris ;
Sauro, Herbert ;
Snoep, Jacky L. ;
Kohn, Kurt ;
Kitano, Hiroaki .
NATURE BIOTECHNOLOGY, 2009, 27 (08) :735-741
[7]   Payao: a community platform for SBML pathway model curation [J].
Matsuoka, Yukiko ;
Ghosh, Samik ;
Kikuchi, Norihiro ;
Kitano, Hiroaki .
BIOINFORMATICS, 2010, 26 (10) :1381-1383
[8]   PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium [J].
Mi, Huaiyu ;
Dong, Qing ;
Muruganujan, Anushya ;
Gaudet, Pascale ;
Lewis, Suzanna ;
Thomas, Paul D. .
NUCLEIC ACIDS RESEARCH, 2010, 38 :D204-D210
[9]   BioPP: a tool for web-publication of biological networks [J].
Viswanathan, Ganesh A. ;
Nudelman, German ;
Patil, Sonali ;
Sealfon, Stuart C. .
BMC BIOINFORMATICS, 2007, 8 (1)