High Entrapment Efficiency of Chitosan/Polylactic Acid/Tripolyphotspate Nanosized Microcapsules for Rapamycin by an Emulsion-Evaporation Approach

被引：124

作者：

Fu, Jing ^{[2
,3
]}

Wang, Daxin ^{[1
]}

Wang, Ting ^{[3
]}

Yang, Wenjing ^{[3
]}

Deng, Yan ^{[4
]}

Wang, Hua ^{[1
]}

Jin, Shiguang ^{[1
]}

He, Nongyue ^{[3
,4
]}

机构：

[1] Yangzhou Univ, Clin Med Coll, Yangzhou 225001, Peoples R China

[2] Dept Publ Hlth, Nanjing 210096, Peoples R China

[3] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Peoples R China

[4] Hunan Univ Technol, Hunan Key Lab Green Packaging & Applicat NanoBio, Zhuzhou 412007, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2010年 / 6卷 / 06期

关键词：

Chitosan; Polylactic Acid; Entrapment Efficiency; Sustained Release Solvent; Rapamycin; DRUG-DELIVERY SYSTEMS; IN-VITRO; NANOPARTICLES; NANOCAPSULES; VIVO; PHARMACOKINETICS; DEGRADATION; MICELLES; RELEASE;

D O I：

10.1166/jbn.2010.1135

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Chitosan (CS)/polylactic acid (PLA)/tripolyphotspate (TPP) nanosized microcapsules were prepared by emulsion-evaporation. The average diameter of the obtained nanosized microcapsules was around 100 similar to 300 nm, and a homogeneous size distribution and good dispersion were observed. The entrapment efficiency of the nanosized CS/PLA/TPP microcapsules for rapamycin was increased with the increase in amount of PLA. When the ratio of CS to PLA was 80 to 20, the entrapment efficiency of CS/PLA/TPP nanosized microcapsules for rapamycin reached the highest (89.8 +/- 1.72%). It was also observed that The RAPA entrapment efficiency reached its highest at 20% of addition dosage of RAPA.

引用

页码：725 / 728

页数：4

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