A physical map of the human genome

被引：579

作者：

McPherson, JD

Marra, M

Hillier, L

Waterston, RH

Chinwalla, A

Wallis, J

Sekhon, M

Wylie, K

Mardis, ER

Wilson, RK

Fulton, R

Kucaba, TA

Wagner-McPherson, C

Barbazuk, WB

Gregory, SG

Humphray, SJ

French, L

Evans, RS

Bethel, G

Whittaker, A

Holden, JL

McCann, OT

Dunham, A

Soderlund, C

Scott, CE

Bentley, DR

Schuler, G

Chen, HC

Jang, WH

Green, ED

Idol, JR

Maduro, VVB

Montgomery, KT

Lee, E

Miller, A

Emerling, S

Kucherlapati, R

Gibbs, R

Scherer, S

Gorrell, JH

Sodergren, E

Clerc-Blankenburg, K

Tabor, P

Naylor, S

Garcia, D

de Jong, PJ

Catanese, JJ

Nowak, N

Osoegawa, K

Qin, SZ

机构：

[1] Washington Univ, Sch Med, Genome Sequencing Ctr, Dept Genet, St Louis, MO 63108 USA

[2] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

[3] NHGRI, NIH, Bethesda, MD 20892 USA

[4] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

[5] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

[6] Univ Texas San Antonio, San Antonio, TX 78285 USA

[7] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[8] Inst Syst Biol, Multimegabase Sequencing Ctr, Seattle, WA 98105 USA

[9] Fred Hutchinson Canc Res Inst, Div Human Biol, Seattle, WA 98109 USA

[10] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[11] NCI, Dept Genet, Med Branch, Washington, DC USA

[12] Genoscope, Ctr Natl Sequencage, F-91057 Evry, France

[13] US DOE, Joint Genome Inst, Walnut Creek, CA USA

[14] Stanford Univ, Stanford Human Genome Ctr, Sch Med, Stanford, CA 94305 USA

[15] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[16] Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA

[17] Univ Calif Santa Cruz, Dept Comp Sci, Santa Cruz, CA 95064 USA

[18] Univ Calif Santa Cruz, Dept Biol, Santa Cruz, CA 95064 USA

[19] Univ Calif Santa Cruz, Dept Math, Santa Cruz, CA 95064 USA

[20] British Columbia Canc Res Ctr, Vancouver, BC V5Z 4E6, Canada

[21] Inst Mol Biotechnol, Dept Genome Anal, D-07745 Jena, Germany

[22] Univ Kiel, Inst Human Genet, D-24098 Kiel, Germany

[23] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA

[24] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90024 USA

[25] RIKEN, Genom Sci Ctr, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[26] Keio Univ, Sch Med, Dept Mol Biol, Shinjuku Ku, Tokyo 1608582, Japan

[27] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

[28] Deutsch Krebsforschungszentrum, Abt Mol Genomanal, D-69120 Heidelberg, Germany

来源：

NATURE | 2001年 / 409卷 / 6822期

关键词：

D O I：

10.1038/35057157

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.

引用

页码：934 / 941

页数：8

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