Novel stereoselective synthesis of 1-(β-D- and α-L-glycopyranosyl)-5-methyl-1H-1,2,4-triazoles

被引：3
|
作者：
Yu, JX
Li, ZJ
Lu, WJ
Zhang, S
Cai, MS
机构：
[1] Xinjiang Univ, Dept Chem, Wulumqi 830046, Peoples R China
[2] Peking Univ, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
[3] Wuyi Univ, Dept Chem, Jiangmen 529020, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 17期
关键词：
D O I：
10.1016/S0957-4166(03)00491-9
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
1-(beta-D- and alpha-L-Glycopyranosyl)-5-methyl-1H-1,2,4-triazoles 7. 13-15 were synthesized stereoselectively from the corresponding glycopyranosyl aminoguanidine nitrates 1-3 in boiling acetic anhydride or from N-1-(acetylated -beta- or or alpha-L-glycopyranosylamino)-N-1,N-2,N-3-triacetylguanidines 8-10 using catalytic amounts of NaOMe. Structures were confirmed by elemental analyses, IR. NMR and MS and possible mechanisms are discussed. In vitro antitumor and immuno activities are presented. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2507 / 2513
页数：7
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