The Future of ANCA-associated Vasculitis

被引：8
作者：
Holle, Julia U. [1 ]
Wieczorek, Stefan [2 ]
Gross, Wolfgang L. [1 ]
机构：
[1] Univ Hosp Schleswig Holstein, Vasc Ctr, Dept Rheumatol & Clin Immunol, D-24576 Bad Bramstedt, Germany
[2] Ruhr Univ Bochum, Dept Human Genet, D-44780 Bochum, Germany
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2010年 / 36卷 / 03期
关键词：
ANCA-associated vasculitis; Wegener's granulomatosis; Clinical manifestations; Treatment; ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; CIRCULATING ENDOTHELIAL-CELLS; CHURG-STRAUSS-SYNDROME; WEGENERS-GRANULOMATOSIS; RANDOMIZED-TRIAL; RISK-FACTOR; DISEASE; PROTEINASE-3; ANTIBODIES; NEUTROPHILS;
D O I：
10.1016/j.rdc.2010.05.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The introduction of cyclophosphamide for treatment and the detection of antineutrophil cytoplasmatic antibodies (ANCA) as a seromarker for ANCA-associated vasculitis (AAV) have been the most important milestones in the history of AAV Nevertheless, there are still many issues to resolve to fully understand the pathogenesis of AAV and to improve patient outcomes There is a need for diagnostic criteria; treatment strategies need further improvement to reduce the toxicity of conventional immunosuppressants such as cyclophosphamide The elucidation of the genetic background in patients with AAV and the role of granulomatous lesions found in Wegener's granulomatosis are required to fully understand the pathophysiology of AAV
引用
收藏
页码：609 / +
页数：15
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