Genetic risk factors for chronic obstructive pulmonary disease

被引：31
作者：
Sandford, AJ
Paré, PD
机构：
[1] St Pauls Hosp, Ctr Hlth Evaluat & Outcomes Sci, Vancouver, BC V6Z 1Y6, Canada
[2] Univ British Columbia, Pulm Res Lab, Vancouver, BC V5Z 1M9, Canada
[3] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1M9, Canada
来源：
CLINICS IN CHEST MEDICINE | 2000年 / 21卷 / 04期
关键词：
D O I：
10.1016/S0272-5231(05)70173-8
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
There is convincing epidemiologic evidence of genetic susceptibility to chronic obstructive pulmonary disease (COPD). Identification of susceptibility genes could yield important insights into the pathogenesis of COPD and may provide targets for therapeutic intervention. Deficiency of alpha(1)-antitrypsin is the only well-established genetic risk factor for COPD, but several other genes are implicated in the pathogenesis of this disease, Genetic factors may also modify the disease phenotype without being directly involved in the pathogenesis.
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收藏
页码：633 / +
页数：12
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