Synthesis, Bioactivity, and the Anion-Binding Property of 2-Sulfydryl-1,3,4-thiodiazole Derivatives

被引：4

作者：

Shang, Xuefang ^{[1
]}

Li, Wanli ^{[2
]}

Wei, Xiaofang ^{[3
]}

Zhang, Huanle ^{[3
]}

Fu, Zhiyuan ^{[3
]}

Zhang, Jinlian ^{[3
]}

Xu, Xiufang ^{[4
]}

机构：

[1] Xinxiang Med Univ, Dept Chem, Xinxiang 453003, Henan, Peoples R China

[2] Xinxiang Med Univ, Dept Immun, Xinxiang 453003, Henan, Peoples R China

[3] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China

[4] Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China

来源：

HETEROATOM CHEMISTRY | 2015年 / 26卷 / 02期

基金：

中国国家自然科学基金;

关键词：

SELECTIVE RECOGNITION; PHOTOPHYSICAL PROPERTIES; CHEMOSENSORS; RECEPTOR; ACETATE;

D O I：

10.1002/hc.21239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new compounds (1 and 2) containing 2-sulfydryl-1,3,4-thiodiazole have been synthesized and optimized. They both showed wide antibacterial activity for colon bacillus, Staphylococcus aureus, S. albus, dysentery bacillus and inferior activity for Bacillus subtilis. In addition, their binding properties were evaluated for biologically important anions (F-, Cl-, Br-, I-, AcO-, and H2PO4-) by theoretical investigation, UV-vis, fluorescence, and H-1 NMR titration experiments, and they displayed strong binding ability for H2PO4- without the interference of other anions tested. Especially the binding ability of compound 2 containing anthracene with H2PO4- was 1000 times stronger than that of compound 1 containing nitrobenzene. Two compounds based on 2-sulfydryl-1,3,4-thiodiazole have both properties of anion recognition and antibacterial activity.

引用

页码：142 / 149

页数：8

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