Hydrogels in Spinal Cord Injury Repair: A Review

被引:32
作者
Lv, Zhenshan [1 ]
Dong, Chao [2 ]
Zhang, Tianjiao [3 ]
Zhang, Shaokun [1 ]
机构
[1] Jilin Univ, Hosp 1, Jilin Engn Res Ctr Spine & Spine Cord Injury, Dept Spinal Surg, Changchun, Peoples R China
[2] Jilin Univ, Coll Basic Med Sci, Key Lab Pathobiol, Minist Educ, Changchun, Peoples R China
[3] Jilin Univ, Med Insurance Management Dept, China Japan Union Hosp, Changchun, Peoples R China
关键词
spinal cord injury; hydrogel; cells; molecular; repair; review; SELF-ASSEMBLING PEPTIDE; NEURAL STEM-CELLS; ATTENUATES POSTTRAUMATIC INFLAMMATION; FUNCTIONAL RECOVERY; NEURITE OUTGROWTH; AXONAL REGENERATION; NERVE REGENERATION; NEURONAL DIFFERENTIATION; MECHANICAL-PROPERTIES; ALGINATE HYDROGELS;
D O I
10.3389/fbioe.2022.931800
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI is characterized by high disability and tends to occur among the young, seriously affecting patients' lives and quality of life. The key aims of repairing SCI include preventing secondary nerve injury, inhibiting glial scarring and inflammatory response, and promoting nerve regeneration. Hydrogels have good biocompatibility and degradability, low immunogenicity, and easy-to-adjust mechanical properties. While providing structural scaffolds for tissues, hydrogels can also be used as slow-release carriers in neural tissue engineering to promote cell proliferation, migration, and differentiation, as well as accelerate the repair of damaged tissue. This review discusses the characteristics of hydrogels and their advantages as delivery vehicles, as well as expounds on the progress made in hydrogel therapy (alone or combined with cells and molecules) to repair SCI. In addition, we discuss the prospects of hydrogels in clinical research and provide new ideas for the treatment of SCI.
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页数:15
相关论文
共 182 条
[1]   Versatility of Hydrogels: From Synthetic Strategies, Classification, and Properties to Biomedical Applications [J].
Ahmad, Zubair ;
Salman, Saad ;
Khan, Shahid Ali ;
Amin, Abdul ;
Rahman, Zia Ur ;
Al-Ghamdi, Youssef O. ;
Akhtar, Kalsoom ;
Bakhsh, Esraa M. ;
Khan, Sher Bahadar .
GELS, 2022, 8 (03)
[2]   Self-assembling Peptide Reduces Glial Scarring, Attenuates Posttraumatic Inflammation, and Promotes Neurite Outgrowth of Spinal Motor Neurons [J].
Ando, Kei ;
Imagama, Shiro ;
Ito, Zenya ;
Kobayashi, Kazuyoshi ;
Hida, Tetsuro ;
Nakashima, Hiroaki ;
Ito, Kenyu ;
Tsushima, Mikito ;
Ishikawa, Yoshimoto ;
Matsumoto, Akiyuki ;
Nishida, Koji ;
Nishida, Yoshihiro ;
Ishiguro, Naoki .
SPINE, 2016, 41 (20) :E1201-E1207
[3]   Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury [J].
Ansorena, Eduardo ;
De Berdt, Pauline ;
Ucakar, Bernard ;
Simon-Yarza, Teresa ;
Jacobs, Damien ;
Schakman, Olivier ;
Jankovski, Aleksandar ;
Deumens, Ronald ;
Blanco-Prieto, Maria J. ;
Preat, Veronique ;
des Rieux, Anne .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 455 (1-2) :148-158
[4]   Sulfated Alginates as Heparin Analogues: A Review of Chemical and Functional Properties [J].
Arlov, Oystein ;
Skjak-Braek, Gudmund .
MOLECULES, 2017, 22 (05)
[5]   Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture [J].
Ashton, Randolph S. ;
Banerjee, Akhilesh ;
Punyani, Supriya ;
Schaffer, David V. ;
Kane, Ravi S. .
BIOMATERIALS, 2007, 28 (36) :5518-5525
[6]   Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration [J].
Assuncao-Silva, Rita C. ;
Gomes, Eduardo D. ;
Sousa, Nuno ;
Silva, Nuno A. ;
Salgado, Antonio J. .
STEM CELLS INTERNATIONAL, 2015, 2015
[7]   The effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis [J].
Austin, James W. ;
Kang, Catherine E. ;
Baumann, M. Douglas ;
DiDiodato, Lisa ;
Satkunendrarajah, Kajana ;
Wilson, Jefferson R. ;
Stanisz, Greg J. ;
Shoichet, Molly S. ;
Fehlings, Michael G. .
BIOMATERIALS, 2012, 33 (18) :4555-4564
[8]   PCL/gelatin nanofibrous scaffolds with human endometrial stem cells/Schwann cells facilitate axon regeneration in spinal cord injury [J].
Babaloo, Hamideh ;
Ebrahimi-Barough, Somayeh ;
Derakhshan, Mohammad Ali ;
Yazdankhah, Meysam ;
Lotfibakhshaiesh, Nasrin ;
Soleimani, Masoud ;
Joghataei, Mohammad-Taghi ;
Ai, Jafar .
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (07) :11060-11069
[9]   Spinal cord injuries: how could cell therapy help? [J].
Badner, Anna ;
Siddiqui, Ahad M. ;
Fehlings, Michael G. .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2017, 17 (05) :529-541
[10]   3D Biofabrication Strategies for Tissue Engineering and Regenerative Medicine [J].
Bajaj, Piyush ;
Schweller, Ryan M. ;
Khademhosseini, Ali ;
West, Jennifer L. ;
Bashir, Rashid .
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16, 2014, 16 :247-276