Infection and Alcoholic Liver Disease

被引：31

作者：

Chan, Christine ^{[1
]}

Levitsky, Josh ^{[1
]}

机构：

[1] Northwestern Univ, Div Gastroenterol & Hepatol, Feinberg Sch Med, 676 North St Clair St, Chicago, IL 60611 USA

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 03期

关键词：

Cellular immunity; Infectious disease; Alcoholic hepatitis; Cirrhosis; CHRONIC ETHANOL-CONSUMPTION; TUBERCULOUS PERITONITIS; STREPTOCOCCUS-PNEUMONIAE; PULMONARY TUBERCULOSIS; BACTERIAL-INFECTION; PLASMA ENDOTOXIN; OXIDATIVE STRESS; IMMUNE-SYSTEM; HEPATITIS-C; EXPRESSION;

D O I：

10.1016/j.cld.2016.02.014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acute and chronic alcohol use leads to an impaired immune response and dysregulated inflammatory state that contributes to a markedly increased risk of infection. Via shared mechanisms of immune-mediated injury, alcohol can alter the clinical course of viral infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. These effects are most evident in patients with alcoholic hepatitis and cirrhosis. This article provides an overview of alcohol's effect on the immune system and contribution to the risks and outcomes of specific infectious diseases.

引用

页码：595 / +

页数：13

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