A Rare Case of Chronic Lymphocytic Leukemia with Hypercalcemia Induced by Elevated Parathyroid Hormone-Related Peptides

被引：7

作者：

Kampfenkel, T. ^{[1
]}

Baraniskin, A. ^{[1
]}

Teschendorf, C. ^{[1
]}

Schmiegel, W. ^{[1
]}

Massenkeil, G. ^{[1
,2
]}

机构：

[1] Ruhr Univ Bochum, Knappschaftskrankenhaus, Dept Internal Med, DE-44892 Bochum, Germany

[2] Hosp Guetersloh, Bochum, Germany

来源：

ACTA HAEMATOLOGICA | 2010年 / 124卷 / 01期

关键词：

Chronic lymphocytic leukemia; Hypercalcemia; Lymphoma; Malignancy; Parathyroid hormone-related peptide; RESORPTION IN-VITRO; PROTEIN PTHRP; MALIGNANCY; BONE; LYMPHOMA; DISEASE; VIVO;

D O I：

10.1159/000314646

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypercalcemia in malignancies is a frequent complication, mostly affecting patients with solid tumors or multiple myeloma. Calcium elevation is induced by direct bone infiltration of a tumor mass or through calcium liberation from the skeleton by a humoral mediator. The latter mechanism is referred to as humoral hypercalcemia of malignancy (HHM). Frequent mediators of HHM are parathyroid hormone-related peptides (PTHrP). We report a patient with chronic lymphocytic leukemia and hypercalcemia induced by PTHrP. In contrast to solid tumors and myeloma, PTHrP-induced HHM is very rare in low-grad lymphoma including chronic lymphocytic leukemia. Therapeutical approaches consist of cytoreductive treatment and calcium-lowering therapy with bisphosphonates. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：57 / 60

页数：4

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