Microbial production of 1,3-propanediol from glycerol by Klebsiella pneumoniae under micro-aerobic conditions up to a pilot scale

被引：68

作者：

Liu, Hai-Jun ^{[1
]}

Zhang, Dai-Jia ^{[1
]}

Xu, You-Hai ^{[1
]}

Mu, Ying ^{[1
]}

Sun, Ya-Qin ^{[1
]}

Xiu, Zhi-Long ^{[1
]}

机构：

[1] Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2007年 / 29卷 / 08期

基金：

中国国家自然科学基金;

关键词：

fed-batch fermentation; glycerol; Klebsiella pneumoniae; micro-aerobic conditions; pilot scale; 1,3-propanediol;

D O I：

10.1007/s10529-007-9398-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

1,3-Propanediol (1,3-PD) can be produced from glycerol by Klebsiella pneumoniae under micro-aerobic conditions. Recently, this fed-batch fermentation process has been successfully scaled up to 1 m(3). The final 1,3-PD concentration, molar yield and volumetric productivity of 72 g 1(-1), 57% and 2.1 g 1(-1) h(-1), respectively, are close to those of 75 g 1(-1), 61%, and 2.2 g 1(-1) h(-1) under anaerobic conditions. This process would be suitable for the production of 1,3-PD on a large scale.

引用

页码：1281 / 1285

页数：5

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