Small-Molecule Prodrug Nanoassemblies: An Emerging Nanoplatform for Anticancer Drug Delivery

被引：166

作者：

Li, Guanting ^{[1
]}

Sun, Bingjun ^{[1
]}

Li, Yaqiao ^{[1
]}

Luo, Cong ^{[1
]}

He, Zhonggui ^{[1
]}

Sun, Jin ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Dept Pharmaceut, Shenyang 110016, Peoples R China

来源：

SMALL | 2021年 / 17卷 / 52期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

carrier-free; combination therapy; nanotechnology; prodrug; self-assembly; stimuli-response; SELF-ASSEMBLED NANOPARTICLES; STIMULI-RESPONSIVE NANOCARRIERS; CONJUGATE-FORMING NANOPARTICLES; DOCOSAHEXAENOIC ACID-PACLITAXEL; IN-VITRO; CAMPTOTHECIN PRODRUG; TUMOR MICROENVIRONMENT; VERSATILE NANOPLATFORM; ORGANIC NANOPARTICLES; MULTIDRUG-RESISTANCE;

D O I：

10.1002/smll.202101460

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The antitumor efficiency and clinical translation of traditional nanomedicines is mainly restricted by low drug loading, complex preparation technology, and potential toxicity caused by the overused carrier materials. In recent decades, small-molecule prodrug nanoassemblies (SMP-NAs), which are formed by the self-assembly of prodrugs themselves, have been widely investigated with distinct advantages of ultrahigh drug-loading and negligible excipients-trigged adverse reaction. Benefited from the simple preparation process, SMP-NAs are widely used for chemotherapy, phototherapy, immunotherapy, and tumor diagnosis. In addition, combination therapy based on the accurate co-delivery behavior of SMP-NAs can effectively address the challenges of tumor heterogeneity and multidrug resistance. Recent trends in SMP-NAs are outlined, and the corresponding self-assembly mechanisms are discussed in detail. Besides, the smart stimuli-responsive SMP-NAs and the combination therapy based on SMP-NAs are summarized, with special emphasis on the structure-function relationships. Finally, the outlooks and potential challenges of SMP-NAs in cancer therapy are highlighted.

引用

页数：29

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