Two-Photon Nanoprobe for NIR-II Imaging of Tumour and Biosafety Evaluation

被引：0
|
作者：
Zha, Yiqian [1 ,2 ]
Cui, Xinyuan [3 ]
Liu, Yanlei [1 ,2 ]
Fan, Shanshan [4 ]
Lu, Yi [1 ,2 ]
Cui, Shengsheng [1 ,2 ]
Cui, Daxiang [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Engn Res Ctr Intelligent Diag & Treatmen, Sch Sensing Sci & Engn, Inst Nano Biomed & Engn, Shanghai 200240, Peoples R China
[2] Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China
[3] Tongji Univ, Tong Ji Hosp, Med Imaging Dept, Shanghai 200065, Peoples R China
[4] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, South Campus, Shanghai 201400, Peoples R China
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2022年 / 18卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Two-Photon Nanoprobe; NIR-II Imaging; Tumour; Biosafety Evaluation; THERAPY; CANCER; NANOPARTICLES; CELLS;
D O I：
10.1166/jbn.2022.3275
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
How to develop near-infrared second window (NIR-II, 1000-1700 nm) fluorescent nanoprobes with a uniform size, strong fluorescence signal and good biosafety owns great clinical requirement. Herein we reported that a two photon fluorescent nanoprobe was developed via encapsulating NIR-II-fluorescent molecules into DSPE-PEG, which was effectively endocytosized by cancer cells, and achieved strong NIR-II fluorescence imaging in cancer cells and cancer cell-beard mice models. Prepared NIR-II-fluorescent nanoprobe exhibited rapid metabolism and excellent biocompatibility. In conclusion, the prepared two photon nanoprobe owns good biosafety, and clinical translational prospect in NIR-II fluorescent imaging of tumour in vivo in near future.
引用
收藏
页码：807 / 817
页数：11
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