Two-Photon Nanoprobe for NIR-II Imaging of Tumour and Biosafety Evaluation

被引：0

作者：

Zha, Yiqian ^{[1
,2
]}

Cui, Xinyuan ^{[3
]}

Liu, Yanlei ^{[1
,2
]}

Fan, Shanshan ^{[4
]}

Lu, Yi ^{[1
,2
]}

Cui, Shengsheng ^{[1
,2
]}

Cui, Daxiang ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Engn Res Ctr Intelligent Diag & Treatmen, Sch Sensing Sci & Engn, Inst Nano Biomed & Engn, Shanghai 200240, Peoples R China

[2] Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China

[3] Tongji Univ, Tong Ji Hosp, Med Imaging Dept, Shanghai 200065, Peoples R China

[4] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, South Campus, Shanghai 201400, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2022年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Two-Photon Nanoprobe; NIR-II Imaging; Tumour; Biosafety Evaluation; THERAPY; CANCER; NANOPARTICLES; CELLS;

D O I：

10.1166/jbn.2022.3275

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

How to develop near-infrared second window (NIR-II, 1000-1700 nm) fluorescent nanoprobes with a uniform size, strong fluorescence signal and good biosafety owns great clinical requirement. Herein we reported that a two photon fluorescent nanoprobe was developed via encapsulating NIR-II-fluorescent molecules into DSPE-PEG, which was effectively endocytosized by cancer cells, and achieved strong NIR-II fluorescence imaging in cancer cells and cancer cell-beard mice models. Prepared NIR-II-fluorescent nanoprobe exhibited rapid metabolism and excellent biocompatibility. In conclusion, the prepared two photon nanoprobe owns good biosafety, and clinical translational prospect in NIR-II fluorescent imaging of tumour in vivo in near future.

引用

页码：807 / 817

页数：11

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