Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions

被引:31
|
作者
Kamangar, Sarfaraz [1 ]
Badruddin, Irfan Anjum [1 ]
Govindaraju, Kalimuthu [2 ]
Nik-Ghazali, N. [1 ]
Badarudin, A. [1 ]
Viswanathan, Girish N. [3 ]
Ahmed, N. J. Salman [4 ]
Khan, T. M. Yunus [1 ]
机构
[1] Univ Malaya, Dept Mech Engn, Kuala Lumpur 50603, Malaysia
[2] Mekelle Univ, Dept Mech & Ind Engn, Mekelle, Ethiopia
[3] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne PL68DH, Tyne & Wear, England
[4] Sultan Qaboos Univ, Dept Mech & Ind Engn, 33 Al Khoud, Muscat 123, Oman
关键词
Coronary artery; Non-Newtonian flow; Stenosis; FFR; FRACTIONAL FLOW RESERVE; BLOOD-FLOW; STENOSIS; WALL; BIFURCATION; PATTERNS; PARAMETERS; VELOCITY; PLAQUES; INDEX;
D O I
10.1007/s11517-016-1604-8
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress was observed for 90% AS as compared to other models that could result in the rupture of coronary artery. The FFR of 90% AS is found to be considerably low.
引用
收藏
页码:1451 / 1461
页数:11
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