Cancer-free aging: Insights from Spalax ehrenbergi superspecies

被引：16
作者：
Alejandro Lagunas-Rangel, Francisco [1 ]
机构：
[1] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, CINVESTAV, Dept Genet & Mol Biol, Ave Inst Politecn Nacl 2508, Mexico City 07360, DF, Mexico
来源：
AGEING RESEARCH REVIEWS | 2018年 / 47卷
关键词：
Blind mole rat; Cancer resistance; Longevity; Hypoxia; Cellular damage; SUBTERRANEAN MOLE-RATS; THYROID-FUNCTION; DNA-DAMAGE; HYPOXIA; RESISTANCE; TOLERANCE; HEPARANASE; P53; ERYTHROPOIETIN; INHIBITION;
D O I：
10.1016/j.arr.2018.06.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding of links between cancer and ageing is more important than ever. Spalax is considered an excellent model for ageing and, additionally, for cancer research, due to not show clear age-related phenotypic changes and not develop spontaneous tumours, despite its relatively long lifespan (similar to 20 years in captivity). Thereby, the purpose of this review is to summarize the recent knowledge on Spalax, with a particular emphasis on the molecular mechanisms associated with their longevity and cancer resistance.
引用
收藏
页码：18 / 23
页数：6
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