Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

被引:377
|
作者
Tapeinos, Christos [1 ]
Battaglini, Matteo [1 ,2 ]
Ciofani, Gianni [1 ,3 ]
机构
[1] Ist Italiano Tecnol, Smart Biointerfaces, Viale Rinaldo Piaggio 34, I-56025 Pontedera, PI, Italy
[2] Scuola Super Sant Anna, Biorobot Inst, Viale Rinaldo Piaggio 34, I-56025 Pontedera, PI, Italy
[3] Politecn Torino, Dept Mech & Aerosp Engn, Corso Duca Abruzzi 24, I-10129 Turin, Italy
基金
欧洲研究理事会;
关键词
SLNs; NLCs; Neurodegenerative diseases; Glioblastoma multiforme; BBB; DRUG-DELIVERY-SYSTEMS; EFFICIENT FORMULATION APPROACH; CENTRAL-NERVOUS-SYSTEM; IN-VIVO EFFICACY; POLYMERIC NANOPARTICLES; INTRANASAL DELIVERY; ALZHEIMERS-DISEASE; CORE NANOCAPSULES; GENE DELIVERY; VITRO;
D O I
10.1016/j.jconrel.2017.08.033
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a category of versatile drug delivery systems that have been used in the biomedical field for > 25 years. SLNs and NLCs have been used for the treatment of various diseases including cardiovascular and cerebrovascular, and are considered a standard treatment for the latter, due to their inherent ability to cross the blood brain barrier (BBB). In this review, a presentation of the most important brain diseases (brain cancer, ischemic stroke, Alzheimer's disease, Parkinson's disease and multiple sclerosis) is approached, followed by the basic fabrication techniques of SLNs and NLCs. A detailed description of the reported studies of the last seven years, of active and passive targeting SLNs and NLCs for the treatment of glioblastoma multiforme and of other brain cancers, as well as for the treatment of neurodegenerative diseases is also carried out. Finally, a brief description of the advantages, the disadvantages, and the future perspectives in the use of these nanocarriers is reported, aiming at giving an insight of the limitations that have to be overcome in order to result in a delivery system with high therapeutic efficacy and without the limitations of the existing nano-systems.
引用
收藏
页码:306 / 332
页数:27
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