The impact of cold ischemia time on renal transplant outcome

被引：87
作者：
Ponticelli, Claudio E. [1 ]
机构：
[1] Humanitas Clin & Res Ctr, Nephrol & Dialysis Unit, I-20089 Milan, Italy
来源：
KIDNEY INTERNATIONAL | 2015年 / 87卷 / 02期
关键词：
KIDNEY; INJURY;
D O I：
10.1038/ki.2014.359
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Cold ischemia triggers a cascade of noxious effects, which are amplified by restoration of blood supply reperfusion. These injuries generate inflammatory and immune responses that may potentially result in delayed graft function, enhanced alloimmune reactivity, and development of progressive pathological changes. Debout et al. outline the clinical importance of cold ischemia time in renal transplantation by demonstrating that each additional hour of cold ischemia can increase the risk of allograft failure and death.
引用
收藏
页码：272 / 275
页数：4
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共 8 条
  • [1] Regulation of Humoral Immunity by Complement
    Carroll, Michael C.
    Isenman, David E.
    [J]. IMMUNITY, 2012, 37 (02) : 199 - 207
  • [2] Summary of FDA Workshop on Ischemia Reperfusion Injury in Kidney Transplantation
    Cavaille-Coll, M.
    Bala, S.
    Velidedeoglu, E.
    Hernandez, A.
    Archdeacon, P.
    Gonzalez, G.
    Neuland, C.
    Meyer, J.
    Albrecht, R.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (05) : 1134 - 1148
  • [3] Each additional hour of cold ischemia time significantly increases the risk of graft failure and mortality following renal transplantation
    Debout, Agnes
    Foucher, Yohann
    Trebern-Launay, Katy
    Legendre, Christophe
    Kreis, Henri
    Mourad, Georges
    Garrigue, Valerie
    Morelon, Emmanuel
    Buron, Fanny
    Rostaing, Lionel
    Kamar, Nassim
    Kessler, Michele
    Ladriere, Marc
    Poignas, Alexandra
    Blidi, Amina
    Soulillou, Jean-Paul
    Giral, Magali
    Dantan, Etienne
    [J]. KIDNEY INTERNATIONAL, 2015, 87 (02) : 343 - 349
  • [4] Role and mechanism of action of complement in regulating T cell immunity
    Dunkelberger, Jason R.
    Song, Wen-Chao
    [J]. MOLECULAR IMMUNOLOGY, 2010, 47 (13) : 2176 - 2186
  • [5] Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Go, AS
    Chertow, GM
    Fan, DJ
    McCulloch, CE
    Hsu, CY
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (13) : 1296 - 1305
  • [6] Impact of Cold Ischemia Time on Graft Survival Among ECD Transplant Recipients: A Paired Kidney Analysis
    Kayler, L. K.
    Magliocca, J.
    Zendejas, I.
    Srinivas, T. R.
    Schold, J. D.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 (12) : 2647 - 2656
  • [7] Macrophage Phenotype Controls Long-Term AKI Outcomes-Kidney Regeneration versus Atrophy
    Lech, Maciej
    Groebmayr, Regina
    Ryu, Mi
    Lorenz, Georg
    Hartter, Ingo
    Mulay, Shrikant R.
    Susanti, Heni Eka
    Kobayashi, Koichi S.
    Flavell, Richard A.
    Anders, Hans-Joachim
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 25 (02): : 292 - 304
  • [8] Acute Kidney Injury in the Elderly
    Rosner, Mitchell H.
    [J]. CLINICS IN GERIATRIC MEDICINE, 2013, 29 (03) : 565 - +
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