Filling-in after focal loss of photoreceptors in rat retina

被引:31
作者
Busch, EM
Gorgels, TGMF
van Norren, D
机构
[1] Acad Hosp Utrecht, Dept Ophthalmol, Fc Donders Inst, NL-3508 GA Utrecht, Netherlands
[2] Aeromed Ctr, NL-3769 ZG Soesterberg, Netherlands
关键词
retina; light damage; photoreceptor; repair; experimental; rat; UVA;
D O I
10.1006/exer.1998.0628
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
We investigated the fate of isolated photoreceptor lesions in rat retina over a time span of 6 months. With a carefully selected dose of UV-A (380 nm) a complete loss of photoreceptors was caused in sharply demarcated areas of 200, 400 or 800 mu m wide, without visible damage to other retinal layers. One day after irradiation, all rods were pyknotic. Three weeks later practically all damaged photoreceptors were removed. The size of the lesion had decreased as the surrounding photoreceptors had migrated into the lesion. The outer segment tips had moved inwards up to 200 mu m, but the innermost nuclei in the outer nuclear layer had moved inwards substantially less. The distance over which the photoreceptors migrated increased with lesion size, but only 200 mu m defects were filled-in completely on the level of the outer segments. Between three weeks and six months after irradiation, no further decrease in lesion size occurred. We conclude that after local loss of photoreceptor cells the bordering photoreceptors rapidly shift into the lesion area, but complete filling-in is limited to very small lesions. (C) 1999 Academic Press.
引用
收藏
页码:485 / 492
页数:8
相关论文
共 20 条
[1]   PHOTORECEPTOR ORIENTATION - A GRADED DISTURBANCE BORDERING A REGION OF CHOROIDAL ATROPHY [J].
BEDELL, HE ;
ENOCH, JM ;
FITZGERALD, CR .
ARCHIVES OF OPHTHALMOLOGY, 1981, 99 (10) :1841-1844
[2]   PHOTOCOAGULATION SCAR EXPANSION AFTER LASER THERAPY FOR CHOROIDAL NEOVASCULARIZATION IN DEGENERATIVE MYOPIA [J].
BRANCATO, R ;
PECE, A ;
AVANZA, P ;
RADRIZZANI, E .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 1990, 10 (04) :239-243
[3]   MULLER CELL GFAP EXPRESSION EXHIBITS GRADIENT FROM FOCUS OF PHOTORECEPTOR LIGHT DAMAGE [J].
BURNS, MS ;
ROBLES, M .
CURRENT EYE RESEARCH, 1990, 9 (05) :479-486
[4]   Temporal sequence of changes in rat retina after UV-A and blue light exposure [J].
Busch, EM ;
Gorgels, TGMF ;
van Norren, D .
VISION RESEARCH, 1999, 39 (07) :1233-1247
[5]  
Collier R J, 1989, Prog Clin Biol Res, V314, P569
[6]  
COLLIER RJ, 1989, INVEST OPHTH VIS SCI, V30, P631
[7]   CLINICOPATHOLOGICAL CORRELATION OF LASER LESION EXPANSION AFTER TREATMENT OF CHOROIDAL NEOVASCULARIZATION [J].
DASTGHEIB, K ;
BRESSLER, SB ;
GREEN, WR .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 1993, 13 (04) :345-352
[8]  
ENOCH JM, 1979, DOC OPHTHALMOL, V48, P373
[9]  
Enoch JM, 1991, VISION VISUAL DYSFUN, P280
[10]   FUNCTIONAL SIGN OF REORGANIZATION IN THE VISUAL-SYSTEM OF ADULT CATS - LATERAL GENICULATE NEURONS WITH DISPLACED RECEPTIVE-FIELDS AFTER LESIONS OF THE NASAL RETINA [J].
EYSEL, UT ;
GONZALEZAGUILAR, F ;
MAYER, U .
BRAIN RESEARCH, 1980, 181 (02) :285-300