Targeting Metastatic Melanoma

被引：53
作者：
Flaherty, Keith T. [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Ctr Canc, Sch Med, Boston, MA 02114 USA
来源：
ANNUAL REVIEW OF MEDICINE, VOL 63 | 2012年 / 63卷
关键词：
BRAF; vemurafenib; GSK2118436; MEK; CTLA-4; ULTRAVIOLET-RADIATION; BRAF; KINASE; MUTATIONS; RAF; INHIBITION; CANCER; CELLS; SUSCEPTIBILITY; EPIDEMIOLOGY;
D O I：
10.1146/annurev-med-050410-105655
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Metastatic melanoma has historically been one of the most treatment-refractory types of cancer. Recent headway has been made in understanding the genetic underpinnings of this cancer. A subset of oncogenic events is amenable to targeting with drug therapy. BRAF-targeted therapies represent the first major breakthrough in systemic therapy for melanoma leveraging the new genetic knowledge. Ongoing translational research seeks to identify the most scientifically rational combination treatment strategies to build on single-agent targeted therapy.
引用
收藏
页码：171 / 183
页数：13
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