Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

被引：171

作者：

Reis, Jordano Ferreira ^{[1
]}

Silva Monteiro, Valter Vinicius ^{[1
]}

Gomes, Rafaelli de Souza ^{[2
]}

do Carmo, Matheus Moraes ^{[1
]}

da Costa, Glauber Vilhena ^{[2
]}

Ribera, Paula Cardoso ^{[1
]}

Monteiro, Marta Chagas ^{[2
]}

机构：

[1] Fed Univ Para UFPA, Sch Pharm, Hlth Sci Inst, BR-66075900 Belem, Para, Brazil

[2] Fed Univ Para UFPA, Pharmaceut Sci Postgrad Program, Hlth Sci Inst, BR-66075900 Belem, Para, Brazil

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2016年 / 14卷

关键词：

Anthocyanins; Oxidative stress; Cardiovascular disease; Polyphenols; Animal models; Human study; LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; INDUCED ENDOTHELIAL DYSFUNCTION; HYDROGEN-PEROXIDE PRODUCTION; OXIDATIVE STRESS MARKERS; CORONARY-HEART-DISEASE; NADPH OXIDASE ACTIVITY; NF-KAPPA-B; LIPID-PEROXIDATION; ANGIOTENSIN-II;

D O I：

10.1186/s12967-016-1076-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these polyphenols have been associated with improved cardiovascular risk profiles as well as decreased comorbidities. Human intervention studies using berries, vegetables, parts of plants and cereals (either fresh or as juice) or purified anthocyanin-rich extracts have demonstrated significant improvements in low density lipoproteins oxidation, lipid peroxidation, total plasma antioxidant capacity, and dyslipidemia as well as reduced levels of CVD molecular biomarkers. This review discusses the use of anthocyanins in animal models and their applications in human medicine, as dietary supplements or as new potent drugs against cardiovascular disease.

引用

页数：16

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