Synthetic lipoprotein as nano-material vehicle in the targeted drug delivery

被引：28

作者：

Zhang, Xueqin ^{[1
]}

Huang, Gangliang ^{[1
]}

机构：

[1] Chongqing Normal Univ, Coll Chem, Act Carbohydrate Res Ctr, Chongqing 401331, Peoples R China

来源：

DRUG DELIVERY | 2017年 / 24卷 / 02期

关键词：

High-density lipoprotein; low-density lipoprotein; recombinant lipoprotein; nano-scaled vehicles; targeted drug delivery; LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; GLIOBLASTOMA-MULTIFORME; LIPID NANOPARTICLES; SCAVENGER RECEPTOR; CHOLESTERYL ESTER; LDL; PACLITAXEL; SIRNA; VITRO;

D O I：

10.1080/10717544.2017.1384518

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High-density lipoprotein (HDL) and low-density lipoprotein (LDL), as human endogenous lipoprotein particles, have low toxicity, high selectivity, and good safety. They can avoid the recognition and clearance of human reticuloendothelial system. These synthetic lipoproteins (sLPs) have been attracted extensive attention as the nanovectors for tumor-targeted drug and gene delivery. Herein, recent advances in the field of anticancer based on these two lipid proteins and recombinant lipoproteins (rLPs) as target delivery vectors were analyzed and discussed.

引用

页码：16 / 21

页数：6

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