Goniomedines A and B: Unprecedented Bisindole Alkaloids Formed through Fusion of Two Indole Moieties via a Dihydropyran Unit

被引：41

作者：

Beniddir, Mehdi A. ^{[1
]}

Martin, Marie-Therese ^{[1
]}

Dau, Marie-Elise Tran Huu ^{[1
]}

Grellier, Philippe ^{[2
]}

Rasoanaivo, Philippe ^{[3
]}

Gueritte, Francoise ^{[1
]}

Litaudon, Marc ^{[1
]}

机构：

[1] CNRS, Lab Ex LERMIT, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

[2] CNRS, Team APE, UMR 7245, Museum Natl Hist Nat, F-75231 Paris, France

[3] Inst Malgache Rech Appl, Antananarivo 102, Madagascar

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

关键词：

D O I：

10.1021/ol301832t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel bisindole alkaloids, goniomedines A (1) and B (2), possessing an unprecedented quebrachamine-pleioarpamine-type skeleton, in which indole moieties are fused via a dihydropyran unit, were isolated from the stem bark of Gonioma malagasy. The structures were elucidated by comprehensive analysis of MS and NMR spectroscopic data. Their absolute configurations were deduced following the comparison of experimental and theoretically calculated ECD spectra and through biogenetic considerations. Goniomedine B (2) exhibited moderate activity against Plasmodium falciparum.

引用

页码：4162 / 4165

页数：4

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