4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides

被引：12

作者：

Ukrainets, I. V. ^{[1
]}

Bevz, O. V. ^{[1
]}

Mospanova, E. V. ^{[2
]}

Savchenkova, L. V. ^{[3
]}

Yankovich, S. I. ^{[3
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

[2] E Ukraine Volodymyr Dahl Natl Univ, Inst Chem Technol, UA-93003 Rubezhnoye, Ukraine

[3] Lugansk State Med Univ, UA-91045 Lugansk, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 48卷 / 02期

关键词：

4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides; amidation; analgesic activity; bromination; ANALGESICS;

D O I：

10.1007/s10593-012-0992-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented.

引用

页码：320 / 326

页数：7

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