New potential biomarkers of acetaminophen-induced hepatotoxicity

被引：10
作者：
Siemionow, Katarzyna [1 ]
Teul, Joanna [1 ]
Dragowski, Pawel [1 ]
Palka, Jerzy [2 ]
Miltyk, Wojciech [1 ]
机构：
[1] Med Univ Bialystok, Dept Pharmaceut Anal, Jana Kilinskiego 1, PL-15089 Bialystok, Poland
[2] Med Univ Bialystok, Dept Med Chem, Bialystok, Poland
来源：
ADVANCES IN MEDICAL SCIENCES | 2016年 / 61卷 / 02期
关键词：
Paracetamol; Hepatotoxicity; Biomarkers; HMGB-1; K-18; INDUCED LIVER-INJURY; GROUP BOX-1 PROTEIN; CELL-DEATH; MITOCHONDRIAL DYSFUNCTION; MECHANISTIC BIOMARKERS; CIRCULATING MICRORNAS; MASS-SPECTROMETRY; OXIDATIVE STRESS; TRANSGENIC MICE; KERATIN; 18;
D O I：
10.1016/j.advms.2016.05.001
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Acetaminophen (APAP) is one of the most common antipyretic and analgesic drugs. Despite various precautions patients use APAP in amounts exceeding acceptable daily doses. APAP overdosing contributes to APAP intoxication, which leads to acute liver injury or necessity of exigent liver transplantation. Biomarkers that can be helpful in early diagnosis of liver injury during APAP overdosing are studied worldwide. This review presents recent reports on new potential biomarkers and their prospective application in clinical practice. (C) 2016 Medical University of Bialystok. Published by Elsevier Sp. z o.o. All rights reserved.
引用
收藏
页码：325 / 330
页数：6
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