Development and evaluation of tetrapod-shaped granular artificial bones

被引：18

作者：

Choi, Sungjin ^{[1
,2
]}

Liu, I-Ii ^{[1
]}

Yamamoto, Kenichi ^{[2
]}

Igawa, Kazuyo ^{[3
]}

Mochizuki, Manabu ^{[1
]}

Sakai, Takamasa ^{[3
]}

Echigo, Ryosuke ^{[1
]}

Honnami, Muneki ^{[1
]}

Suzuki, Shigeki ^{[4
]}

Chung, Ung-il ^{[2
,3
]}

Sasaki, Nobuo ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Vet Surg, Bunkyo Ku, Tokyo 1138657, Japan

[2] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1130033, Japan

[3] Univ Tokyo, Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1130033, Japan

[4] NEXT21 KK, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ACTA BIOMATERIALIA | 2012年 / 8卷 / 06期

基金：

日本学术振兴会;

关键词：

Bone graft; Calcium phosphate; Intergranular pores; Mechanical properties; Tetrapod; BETA-TRICALCIUM PHOSPHATE; CALCIUM-PHOSPHATE; POROUS HYDROXYAPATITE; OCTACALCIUM PHOSPHATE; PORE-SIZE; IN-VITRO; DEFECTS; CELLS; GRAFT; CEMENT;

D O I：

10.1016/j.actbio.2012.02.019

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We have developed a novel form of granular artificial bone "Tetrabones" with a homogeneous tetrapod shape and uniform size. Tetrabones are four armed structures that accumulate to form the intergranular pores that allow invasion of cells and blood vessels. In this study we evaluated the physicochemical characteristics of Tetrabones in vitro, and compared their biological and biomechanical properties in vivo to those of conventional beta-tricalcium phosphate (beta-TCP) granule artificial bone. Both the rupture strength and elastic modulus of Tetrabone particles were higher than those of beta-TCP granules in vitro. The connectivity of intergranular pores 100, 300, and 400 pm in size were higher in Tetrabones than in the beta-TCP granules. Tetrabones showed similar osteoconductivity and biomechanical stiffness to beta-TCP at 2 months after implantation in an in vivo study of canine bone defects. These results suggest that Tetrabones may be a good bone graft material in bone reconstruction. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：2340 / 2347

页数：8

共 44 条

[1] Complications of iliac crest bone graft harvesting [J].

Arrington, ED ;

Smith, WJ ;

Chambers, HG ;

Bucknell, AL ;

Davino, NA .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 1996, (329) :300-309

[2] Osteoconduction at porous hydroxyapatite with various pore configurations [J].

Chang, BS ;

Lee, CK ;

Hong, KS ;

Youn, HJ ;

Ryu, HS ;

Chung, SS ;

Park, KW .

BIOMATERIALS, 2000, 21 (12) :1291-1298

[3]

Chang RCS, 2000, INT J ORAL MAX SURG, V29, P54, DOI 10.1034/j.1399-0020.2000.290113.x

[4]

Chawla K, 2011, QUINTESSENCE INT, V42, P291

[5]

Chow LC, 2009, DENT MATER J, V28, P1

[6] In vitro testing of Advanced JAX™ Bone Void Filler System:: species differences in the response of bone marrow stromal cells to β tri-calcium phosphate and carboxymethylcellulose gel [J].

Clarke, S. A. ;

Hoskins, N. L. ;

Jordan, G. R. ;

Henderson, S. A. ;

Marsh, D. R. .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2007, 18 (12) :2283-2290

[7] Healing of an ulnar defect using a proprietary TCP bone graft substitute, JAX™, in association with autologous osteogenic cells and growth factors [J].

Clarke, S. A. ;

Hoskins, N. L. ;

Jordan, G. R. ;

Marsh, D. R. .

BONE, 2007, 40 (04) :939-947

[8] EXPERIMENTAL HYDROXYAPATITE CEMENT CRANIOPLASTY [J].

COSTANTINO, PD ;

FRIEDMAN, CD ;

JONES, K ;

CHOW, LC ;

SISSON, GA .

PLASTIC AND RECONSTRUCTIVE SURGERY, 1992, 90 (02) :174-185

[9] Mercury porosimetry - An inappropriate method for the measurement of pore size distributions in cement-based materials [J].

Diamond, S .

CEMENT AND CONCRETE RESEARCH, 2000, 30 (10) :1517-1525

[10] Bioceramics of calcium orthophosphates [J].

Dorozhkin, Sergey V. .

BIOMATERIALS, 2010, 31 (07) :1465-1485

← 1 2 3 4 5 →