Sex-related differences in association of oxidative stress status with coronary artery disease

被引:41
作者
Vassalle, Cristina [1 ,2 ]
Sciarrino, Rosalia
Bianchi, Sara
Battaglia, Debora
Mercuri, Antonella
Maffei, Silvia
机构
[1] Fdn G Monasterio CNR Reg Toscana, I-56124 Pisa, Italy
[2] CNR, Inst Clin Physiol, I-56124 Pisa, Italy
关键词
Coronary artery disease; menopause; oxidative stress; sex differences; TOTAL ANTIOXIDANT CAPACITY; HORMONE REPLACEMENT THERAPY; C-REACTIVE PROTEIN; HEART-DISEASE; IN-VIVO; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; AUTOMATED-METHOD; RISK-FACTORS; D-ROMS;
D O I
10.1016/j.fertnstert.2011.11.045
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To assess oxidative stress status in coronary artery disease (CAD) patients according to gender. Design: Case-controlled, observational, retrospective study. Setting: Clinical and research center. Patient(s): A total of 55 postmenopausal women and 108 men (mean age: 66 +/- 9 years), including 72 patients with angiographically proven CAD (CAD(+), 19 women) and a group of 91 age-matched controls (CAD(-), 36 women). Intervention(s): None. Main Outcome Measure(s): Oxidant/antioxidant balance as a global index (oxidative index) obtained using two commercial assays (d-ROMs and OXY Adsorbent Test, respectively) for estimation of levels of reactive oxygen metabolites and total antioxidant status. Result(s): There was a statistically significant difference in oxidative stress status between men and women who were CAD(-) (-0.424 +/- 1.3 vs. 0.64 +/- 1.1 arbitrary units, respectively), but the CAD(+) women had oxidative stress levels almost three times those of the CAD(+) men (2.45 +/- 2.5 vs. 0.9 +/- 1.6 arbitrary units, respectively). After adjustment in the multivariate model, age and oxidative stress status in women and diabetes and age in men remained as statistically significant predictors of positive CAD findings. Conclusion(s): Oxidative stress status was a powerful predictor of CAD in women. This result may have important implications for the differences between sexes in CAD physiopathology. (Fertil Steril(R) 2012;97:414-9. (C) 2012 by American Society for Reproductive Medicine.)
引用
收藏
页码:414 / U1112
页数:8
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