The relationship between long-term proton pump inhibitor therapy and skeletal frailty

被引：22
作者：
Lau, Arthur N. [1 ]
Tomizza, Michael [2 ]
Wong-Pack, Matthew [2 ]
Papaioannou, Alexandra [3 ]
Adachi, Jonathan D. [1 ]
机构：
[1] McMaster Univ, Dept Med, Div Rheumatol, Hamilton, ON, Canada
[2] McMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada
[3] McMaster Univ, Dept Med, Div Geriatr, Hamilton, ON, Canada
来源：
ENDOCRINE | 2015年 / 49卷 / 03期
基金：
加拿大健康研究院;
关键词：
Proton-pump inhibitors; Fractures; Osteoporosis; Fragility; BONE-MINERAL DENSITY; HIP FRACTURE; ACID-SECRETION; RISK-FACTORS; WOMEN; HEALTH; SAFETY;
D O I：
10.1007/s12020-015-0576-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Proton pump inhibitors (PPIs) are a commonly prescribed class of medications. Their use has been associated with an increased rate of fractures, most notably hip fractures. However, there does not seem to be a clear association between PPI use and bone mineral density measurements, assessed by dual X-ray absorptiometry. The mechanism by which PPI use increases the risk of fractures remains unclear. This review will summarize the current evidence on this topic.
引用
收藏
页码：606 / 610
页数：5
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