Synthesis and Functionalization of Imidazo[1,2-a]Pyridines and Imidazo[1,2-a]Pyrimidines on Solid Phase Using Suzuki-Miyaura Cross-Coupling Reactions

被引：17
作者：
El Kazzouli, Said [1 ,2 ,3 ]
Berteina-Raboin, Sabine [1 ]
Mouaddib, Abderrahim [2 ]
Guillaumet, Gerald [1 ]
机构：
[1] Univ Orleans, CNRS, Inst Chim Organ & Analyt, UMR 6005, F-45067 Orleans 2, France
[2] Univ Sultan Moulay Slimane, Fac Sci & Tech Beni Mellal, Beni Mellal 23000, Morocco
[3] MAScIR Fdn, Inst Nanomat & Nanotechnol INANOTECH, Rabat 10100, Morocco
来源：
LETTERS IN ORGANIC CHEMISTRY | 2012年 / 9卷 / 02期
关键词：
Imidazo[1,2-a]pyridine imidazo[1,2-a]pyrimidine; microwave irradiations; solid phase synthesis; Suzuki-Miyaura cross-coupling; ANTIVIRAL ACTIVITY; SELECTIVE LIGANDS; BINDING-AFFINITY; ANTIULCER AGENTS; C-NUCLEOSIDES; IN-VIVO; DERIVATIVES; IMIDAZO<1,2-A>PYRIDINES; HETEROARYLATION; ALKENYLATION;
D O I：
10.2174/157017812800221753
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Microwave assisted solid phase synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines by the treatment of polymer-bound alpha-bromoketone with various 2-aminopyridines or 2-aminopyrimidines was achieved. Functionalizations of the 3-positions were realized by the treatment of polymer-bound 3-iodoimidazo[1,2-a]pyridine or polymer-bound 3-iodoimidazo[1,2-a]pyrimidine with various boronic acids under Suzuki-Miyaura reaction conditions. 6-Position of polymer-bound imidazo[1,2-a] pyridine was also functionalized using Suzuki-Miyaura cross-coupling reaction.
引用
收藏
页码：118 / 127
页数：10
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