Advances in the understanding of the aetiology of Dupuytren's disease

被引：24

作者：

Picardo, Natasha E. ^{[1
]}

Khan, Wasirn S. ^{[1
]}

机构：

[1] Royal Natl Orthopaed Hosp, Inst Orthopaed, Stanmore HA7 4LP, Middx, England

来源：

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND | 2012年 / 10卷 / 03期

关键词：

Dupuytren's disease; Dupuytren's contracture; Flexion contracture; Palmar fibromatosis; Dupuytren's diathesis; SMOOTH MUSCLE ACTIN; GROWTH-FACTOR-BETA; EXTRACELLULAR-MATRIX; PALMAR FASCIA; RHEUMATOID-ARTHRITIS; IN-VITRO; CONTRACTURE; EXPRESSION; MYOFIBROBLAST; FIBROBLASTS;

D O I：

10.1016/j.surge.2012.01.004

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Dupuytren's disease is a fibroproliferative disease of the palmar fascia which has been described for centuries, yet the aetiology and pathophysiology remain poorly understood. Surgery and collagenase injections comprise the main therapeutic options but disease recurrence is common. We explore the evidence underlying the current disease theories and outline other potential therapeutic options. (C) 2012 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

引用

页码：151 / 158

页数：8

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