The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia

被引：69
作者：
Li, Hui [1 ]
Chen, Kailan [1 ]
Liu, Maochang [2 ]
Xu, Hua [2 ]
Xu, Qiong [2 ]
机构：
[1] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Clin Pharmacol, 100 Hong Kong Rd, Wuhan 430016, Hubei, Peoples R China
来源：
JOURNAL OF INFECTION | 2020年 / 81卷 / 01期
关键词：
2019 novel coronavirus pneumonia; Lymphocyte subsets; Serum cytokines; Children; INFECTION;
D O I：
10.1016/j.jinf.2020.04.001
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objectives: The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia. Methods: Children with 2019-nCoV pneumonia or with respiratory syncytial virus (RSV) pneumonia were included. Data including lymphocyte subsets and serum cytokines were collected and analyzed. Results: 56 patients were included in the study, 40 children with 2019-nCoV pneumonia and 16 children with RSV pneumonia. Compared with children with RSV pneumonia, patients with 2019-nCoV pneumonia had higher count of CD3+8+ lymphocyte, higher percentages of CD3+, CD3+8+ lymphocytes and a lower percentage of CD19+ lymphocyte. The serum IL-10 level was significantly higher in children with RSV pneumonia. One 2019-nCoV pneumonia child who was with an obvious increase of IL-10 developed severe pneumonia. Conclusions: Immune response played a very important role in the development of 2019-nCoV pneumonia. The effective CD8+ T cell response might influence the severity of 2019-nCoV pneumonia. The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：115 / 120
页数：6
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