Efficient and regioselective functionalization of imidazo[1,2-b]pyridazines via palladium-catalyzed cross-coupling reaction and SNAr

被引：10

作者：

El Akkaoui, A. ^{[1
,2
]}

Koubachi, J. ^{[1
,2
]}

El Kazzouli, S. ^{[1
,2
]}

Berteina-Raboin, S. ^{[1
]}

Mouaddib, A. ^{[2
]}

Guillaumet, G. ^{[1
]}

机构：

[1] Univ Orleans, CNRS, UMR 6005, Inst Chim Organ & Analyt, F-45067 Orleans 2, France

[2] Univ Cadi Ayyad, Fac Sci & Tech, Beni Mellal 23000, Morocco

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 15期

关键词：

D O I：

10.1016/j.tetlet.2008.02.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and aryl at the 3-position of imidazo[1,2-b]pyridazines. Then, at the 6-position, palladium-catalyzed N-arylation and direct SNAr were used to introduce amines and alcohols. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2472 / 2475

页数：4

共 48 条

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