The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis

被引：22
作者：
Hazar-Rethinam, Mehlika [1 ]
Endo-Munoz, Liliana [1 ]
Gannon, Orla [1 ]
Saunders, Nicholas [1 ,2 ]
机构：
[1] Univ Queensland, Diamantina Inst, Epithelial Pathobiol Grp, Princess Alexandra Hosp, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 12期
基金：
英国医学研究理事会;
关键词：
UV; sunburn cells; E2F; apoptosis; SQUAMOUS-CELL CARCINOMA; DNA-DAMAGE RESPONSE; SKIN-CANCER; ULTRAVIOLET-RADIATION; INDUCED ACTIVATION; EXPRESSION; CYCLE; REPAIR; MEMBER; PATHWAYS;
D O I：
10.3390/ijms12128947
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.
引用
收藏
页码：8947 / 8960
页数：14
相关论文
共 92 条
[81]   Sibling rivalry in the E2F family [J].
Trimarchi, JM ;
Lees, JA .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (01) :11-20
[82]   Ultraviolet radiation and skin cancer of humans [J].
Urbach, F .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1997, 40 (01) :3-7
[83]   The sunburn cell: Regulation of death and survival of the keratinocyte [J].
Van Laethem, A ;
Claerhout, S ;
Garmyn, M ;
Agostinis, P .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (08) :1547-1553
[84]   Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation [J].
Walshe, Jennifer ;
Serewko-Auret, Magdalena M. ;
Teakle, Ngari ;
Cameron, Sarina ;
Minto, Kelly ;
Smith, Louise ;
Burcham, Philip C. ;
Russell, Terry ;
Strutton, Geoffrey ;
Griffin, Anthony ;
Clm, Fong-Fong ;
Esworthy, Stephen ;
Reeve, Vivienne ;
Saunders, Nicholas A. .
CANCER RESEARCH, 2007, 67 (10) :4751-4758
[85]   E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo [J].
Wang, DW ;
Russell, JL ;
Johnson, DG .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (10) :3417-3424
[86]   Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice [J].
Wikonkal, NM ;
Remenyik, E ;
Knezevic, D ;
Zhang, WG ;
Liu, M ;
Zhao, HY ;
Berton, TR ;
Johnson, DG ;
Brash, DE .
NATURE CELL BIOLOGY, 2003, 5 (07) :655-660
[87]   E2F6: a member of the E2F family that does not modulate squamous differentiation [J].
Wong, CF ;
Barnes, LM ;
Smith, L ;
Popa, C ;
Serewko-Auret, MM ;
Saunders, NA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 324 (02) :497-503
[88]   E2F modulates keratinocyte squamous differentiation - Implications for E2F inhibition in squamous cell carcinoma [J].
Wong, CF ;
Barnes, LM ;
Dahler, AL ;
Smith, L ;
Serewko-Auret, MM ;
Popa, C ;
Abdul-Jabbar, I ;
Saunders, NA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (31) :28516-28522
[89]   Differential expression of cell survival and cell cycle regulatory proteins in cutaneous squamoproliferative lesions [J].
Wrone-Smith, T ;
Bergstrom, J ;
Quevedo, ME ;
Reddy, V ;
Gutierrez-Steil, C ;
Nickoloff, BJ .
JOURNAL OF DERMATOLOGICAL SCIENCE, 1999, 19 (01) :53-67
[90]   Tumor induction and tissue atrophy in mice lacking E2F-1 [J].
Yamasaki, L ;
Jacks, T ;
Bronson, R ;
Goillot, E ;
Harlow, E ;
Dyson, NJ .
CELL, 1996, 85 (04) :537-548
12345678910