The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis

被引：22

作者：

Hazar-Rethinam, Mehlika ^{[1
]}

Endo-Munoz, Liliana ^{[1
]}

Gannon, Orla ^{[1
]}

Saunders, Nicholas ^{[1
,2
]}

机构：

[1] Univ Queensland, Diamantina Inst, Epithelial Pathobiol Grp, Princess Alexandra Hosp, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 12期

基金：

英国医学研究理事会;

关键词：

UV; sunburn cells; E2F; apoptosis; SQUAMOUS-CELL CARCINOMA; DNA-DAMAGE RESPONSE; SKIN-CANCER; ULTRAVIOLET-RADIATION; INDUCED ACTIVATION; EXPRESSION; CYCLE; REPAIR; MEMBER; PATHWAYS;

D O I：

10.3390/ijms12128947

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.

引用

收藏

页码：8947 / 8960

页数：14

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