Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization

被引：20

作者：

Cheng, Yuli ^{[1
]}

Yu, Yan ^{[1
]}

Zhuang, Qinghui ^{[1
]}

Wang, Lei ^{[2
]}

Zhan, Bin ^{[3
]}

Du, Suqin ^{[1
]}

Liu, Yiqi ^{[1
]}

Huang, Jingjing ^{[1
]}

Hao, Junfeng ^{[4
]}

Zhu, Xinping ^{[1
]}

机构：

[1] Capital Med Univ, Sch Basic Med Sci, Dept Med Microbiol & Parasitol, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing Friendship Hosp, Beijing Inst Trop Med, Beijing 100050, Peoples R China

[3] Baylor Coll Med, Natl Sch Trop Med, Dept Pediat & Mol Virol, Houston, TX 77030 USA

[4] Chinese Acad Sci, Inst Biophys, Core Facil Prot Res, Beijing 100101, Peoples R China

来源：

ISCIENCE | 2022年 / 25卷 / 03期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

RHEUMATOID-ARTHRITIS; OSTEOCLAST; IL-10; MECHANISMS; RANKL;

D O I：

10.1016/j.isci.2022.103979

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Helminths and helminth-derived products hold promise for treating joint bone erosion in rheumatoid arthritis (RA). However, the mechanisms of helminths ameliorating the osteoclastic bone destruction are incompletely understood. Here, we report that Trichinella spiralis infection or treatment with the excreted/secreted products of T. spiralis muscle larvae (MES) attenuated bone erosion and osteoclastogenesis in mice with collage-induced arthritis (CIA) through inhibiting M1 monocyte/macrophage polarization and the production of M1-related proinflammatory cytokines. In vitro, MES inhibited LPS-induced M1 macrophage activation while promoting IL-4-induced M2 macrophage polarization. Same effects of MES were also observed in monocytes derived from RA patients, wherein MES treatment suppressed LPS-induced M1 cytokine production. Moreover, MES treatment attenuated LPS and RANKL co-stimulated osteoclast differentiation from the RAW264.7 macrophages through inhibiting activation of the NF-kappa B rather than MAPK pathway. This study provides insight into the M1 subset as a potential target for helminths to alleviate osteoclastic bone destruction in RA.

引用

页数：23

共 31 条

[31] Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-?B pathways
Yin, Juan
Hu, Tong
Xu, Lijuan
Zhang, Liping
Zhu, Jianyun
Ye, Yulan
Pang, Zhi
[J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 123

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