Antifreeze and Rheological Properties of Injectable Triblock Copolymer Hydrogels with Supramolecular Junctions

被引：6

作者：

Choi, Jewon ^{[1
]}

Kim, Seyoung ^{[1
,2
]}

Mun, Huy Ju ^{[1
]}

Yoo, Jin ^{[3
]}

Choi, Soo-Hyung ^{[2
]}

Char, Kookheon ^{[1
]}

机构：

[1] Seoul Natl Univ, Natl Creat Res Initiat Ctr Intelligent Hybrids, Dept Chem & Biol Engn, Seoul 08826, South Korea

[2] Hongik Univ, Dept Chem Engn, Seoul 04066, South Korea

[3] Korea Inst Sci & Technol KIST, Biomed Res Inst, Ctr Biomat, Seoul 02792, South Korea

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2022年 / 43卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

antifreeze hydrogels; injectability; self-healing; supramolecular interactions; triblock copolymer; BLOCK-COPOLYMERS; B-PEO; CRYOPRESERVATION; CRYSTALLIZATION; NUCLEATION; POLYMER; DIMERS; GELS;

D O I：

10.1002/marc.202100618

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

ABC triblock copolymers composed of hydrophobic poly(epsilon-caprolactone) (PCL), zwitterionic poly(carboxybetaine methacrylate) midblock, and P(PEGMA-UPy0.15) containing supramolecular ureidopyrimidinone moieties, poly(epsilon-caprolactone-block-carboxybetaine methacrylate-block-[poly(ethylene glycol) methyl ether methacrylate-co-(alpha-methacryloyl-omega-(6-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido)hexylcarbamoyloxy)poly(ethylene glycol))]), are investigated to achieve multifunctional antifreeze hydrogels. The PCL and P(PEGMA-UPy0.15) blocks induce the formation of physical network with a hierarchical nanostructure comprising hydrophobic PCL cores and supramolecular junctions, respectively. The super-hydrophilic nature of polyzwitterion midblocks and the confinement effect of the supramolecular junctions enhance the antifreeze performance, where the majority of water molecules remains supercooled below sub-zero temperature. The hydrogel relaxation characterized over a wide range of timescale reveals that the facile dynamics of the supramolecular junctions lead to the self-healing and injectability of the hydrogels. In conjunction with the biodegradable PCL cores, the antifreeze and rheological characteristics of the triblock copolymer hydrogels provide significant potential to use for cryo-preservable and bio-injectable drug storage and delivery.

引用

页数：8

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