Research strategies to improve snakebite treatment: Challenges and progress

被引：73

作者：

Harrison, Robert A. ^{[1
]}

Cook, Darren A. ^{[1
]}

Renjifo, Camila ^{[1
]}

Casewell, Nicholas R. ^{[1
]}

Currier, Rachel B. ^{[1
]}

Wagstaff, Simon C. ^{[1
]}

机构：

[1] Univ Liverpool, Liverpool Sch Trop Med, Alistair Reid Venom Res Unit, Liverpool L3 5QA, Merseyside, England

来源：

JOURNAL OF PROTEOMICS | 2011年 / 74卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

Snake; Antivenom affordability; Venom gland transcriptome; Epitope-string immunogen; Camelid IgG/VHH; Global Snakebite Initiative; LOCAL TISSUE-DAMAGE; ANDROCTONUS-AUSTRALIS-HECTOR; VENOM GLAND TRANSCRIPTOME; SUB-SAHARAN AFRICA; METALLOPROTEINASE INHIBITOR BATIMASTAT; SCORPION CENTRUROIDES-NOXIUS; CHAIN ANTIBODY FRAGMENT; EXPRESSED SEQUENCE TAGS; NECROSIS FACTOR-ALPHA; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.jprot.2011.06.019

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Antivenom is an effective treatment of snakebite but, because of the complex interplay of fiscal, epidemiological, therapeutic efficacy and safety issues, the mortality of snakebite remains unacceptably high. Efficiently combating this high level of preventable death amongst the world's most disadvantaged communities requires the globally-coordinated action of multiple intervention programmes. This is the overall objective of the Global Snakebite Initiative. This paper describes the challenges facing the research community to develop snakebite treatments that are more efficacious, safe and affordable than current therapy. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1768 / 1780

页数：13

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