Graphene oxide enriched with oxygen-containing groups: on the way to an increase of antioxidant activity and biocompatibility

被引：40

作者：

Abdelhalim, Abdelsattar O. E. ^{[1
,4
]}

Meshcheriakov, Anatolii A. ^{[1
,2
]}

Maistrenko, Dmitrii N. ^{[3
]}

Molchanov, Oleg E. ^{[3
]}

Ageev, Sergei, V ^{[1
,2
]}

Ivanova, Daria A. ^{[2
]}

Iamalova, Nailia R. ^{[2
]}

Luttsev, Mikhail D. ^{[2
]}

Vasina, Lubov V. ^{[2
]}

Sharoyko, Vladimir V. ^{[1
,2
,3
]}

Semenov, Konstantin N. ^{[1
,2
,3
]}

机构：

[1] St Petersburg State Univ, Inst Chem, 26 Univ Skii Prospect, St Petersburg 198504, Russia

[2] Pavlov First St Petersburg State Med Univ, 6-8 Lva Tolstogo St, St Petersburg 197022, Russia

[3] AM Granov Russian Res Ctr Radiol & Surg Technol, 70 Leningradskaya St, St Petersburg 197758, Russia

[4] Natl Ctr Social & Criminol Res NCSCR, Environm Res Dept, 4 Agouza, Giza 11561, Egypt

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2022年 / 210卷

基金：

俄罗斯基础研究基金会;

关键词：

Graphene Oxide; Identification; Biocompatibility; HSA; DPPH; Cytotoxicity; HUMAN SERUM-ALBUMIN; MECHANICAL-PROPERTIES; DNA; NANOMATERIALS; GENOTOXICITY; CHEMISTRY; NANOCOMPOSITES; ANTIBACTERIAL; CYTOTOXICITY; FLUORESCENCE;

D O I：

10.1016/j.colsurfb.2021.112232

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The article is dedicated to the comprehensive biocompatibility investigation of synthesised graphene oxide (GO) enriched with oxygen-containing functional groups (similar to 85%). GO was synthesised through a modified Hummers and Offeman's method and characterised using C-13 NMR, Raman, and IR spectroscopy, XRD, HRTEM, along with size dimensions and zeta-potentials in aqueous dispersions. Biocompatibility study included tests on haemo-compatibility (haemolysis, platelet aggregation, binding to human serum albumin and its esterase activity), antioxidant activity (2,2-diphenyl-1-picrylhydrazyl reaction, NO-radical uptake, Radachlorin photobleaching, photo-induced haemolysis), genotoxicity using DNA comet assay, as well as metabolic activity and proliferation of HEK293 cells.

引用

页数：10

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