Graphene oxide enriched with oxygen-containing groups: on the way to an increase of antioxidant activity and biocompatibility

被引：35
作者：
Abdelhalim, Abdelsattar O. E. [1 ,4 ]
Meshcheriakov, Anatolii A. [1 ,2 ]
Maistrenko, Dmitrii N. [3 ]
Molchanov, Oleg E. [3 ]
Ageev, Sergei, V [1 ,2 ]
Ivanova, Daria A. [2 ]
Iamalova, Nailia R. [2 ]
Luttsev, Mikhail D. [2 ]
Vasina, Lubov V. [2 ]
Sharoyko, Vladimir V. [1 ,2 ,3 ]
Semenov, Konstantin N. [1 ,2 ,3 ]
机构：
[1] St Petersburg State Univ, Inst Chem, 26 Univ Skii Prospect, St Petersburg 198504, Russia
[2] Pavlov First St Petersburg State Med Univ, 6-8 Lva Tolstogo St, St Petersburg 197022, Russia
[3] AM Granov Russian Res Ctr Radiol & Surg Technol, 70 Leningradskaya St, St Petersburg 197758, Russia
[4] Natl Ctr Social & Criminol Res NCSCR, Environm Res Dept, 4 Agouza, Giza 11561, Egypt
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2022年 / 210卷
基金：
俄罗斯基础研究基金会;
关键词：
Graphene Oxide; Identification; Biocompatibility; HSA; DPPH; Cytotoxicity; HUMAN SERUM-ALBUMIN; MECHANICAL-PROPERTIES; DNA; NANOMATERIALS; GENOTOXICITY; CHEMISTRY; NANOCOMPOSITES; ANTIBACTERIAL; CYTOTOXICITY; FLUORESCENCE;
D O I：
10.1016/j.colsurfb.2021.112232
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The article is dedicated to the comprehensive biocompatibility investigation of synthesised graphene oxide (GO) enriched with oxygen-containing functional groups (similar to 85%). GO was synthesised through a modified Hummers and Offeman's method and characterised using C-13 NMR, Raman, and IR spectroscopy, XRD, HRTEM, along with size dimensions and zeta-potentials in aqueous dispersions. Biocompatibility study included tests on haemo-compatibility (haemolysis, platelet aggregation, binding to human serum albumin and its esterase activity), antioxidant activity (2,2-diphenyl-1-picrylhydrazyl reaction, NO-radical uptake, Radachlorin photobleaching, photo-induced haemolysis), genotoxicity using DNA comet assay, as well as metabolic activity and proliferation of HEK293 cells.
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页数：10
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