Opinion - Taking our breath away: dendritic cells in the pathogenesis of asthma

被引：276
作者：
Lambrecht, BN [1 ]
Hammad, H [1 ]
机构：
[1] Erasmus MC, Dept Pulm Med, NL-3015 GE Rotterdam, Netherlands
来源：
NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 12期
关键词：
D O I：
10.1038/nri1249
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cells (DCs) are mainly known for their capacity to induce primary immune responses. Here, we propose that DCs are similarly essential for controlling effector T-cell responses and, therefore, might have a role in T-cell-mediated diseases. In the case of asthma, airway DCs are essential for controlling T helper 2 (TH2)-dependent eosinophilic airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.
引用
收藏
页码：994 / 1003
页数：10
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